宫颈癌患者血清Hmga1 CK19及CA125水平与病情严重程度的关系研究  

Relationship between Levels of Serum Hmga1 CK19 and CA125 and the Severity of Cervical Cancer

作　　者：康永军 李敏[1] 张晓慧[1] 李慧蓉[1] KANG Yongjun;LI Min;ZHANG Xiaohui(The First Affiliated Hospital of Anhui Medical University,Anhui Hefei 230022,China)

机构地区：[1]安徽医科大学第一附属医院妇产科,安徽合肥230022

出　　处：《河北医学》2020年第10期1604-1608,共5页Hebei Medicine

基　　金：安徽省科技攻关计划项目,(编号:2015056713)。

摘　　要：目的:研究宫颈癌患者血清中高迁移率蛋白a1(Hmga1)、细胞角蛋白(CK)19及糖类抗原(CA)125水平与病情严重程度的关系,以期为临床诊断与病情评估提供依据。方法:回顾性分析2019年1月至2019年6月于我院确诊的70例宫颈癌患者(宫颈癌组)的临床资料,并收集同期行妇科高级别肿瘤筛查发现的40例宫颈上皮内瘤变(CIN)患者(癌前病变组)及30例健康女性(对照组)的临床资料进行对比,比较三组血清中Hmga1、CK19及CA125水平,并分析其与宫颈癌病情严重程度的关系。结果:血清中Hmga1、CK19及CA125水平比较,宫颈癌组>癌前病变组>对照组,差异有显著性(P<0.05)。宫颈癌组中,不同肿瘤直径、病理类型患者血清中Hmga1、CK19及CA125水平无明显差异(P>0.05),而Ⅲ~Ⅳ期患者血清中Hmga1、CK19及CA125水平明显高于Ⅰ~Ⅱ期者,中低分化患者血清中Hmga1、CK19及CA125水平明显高于高分化者,伴淋巴结转移患者血清中Hmga1、CK19及CA125水平明显高于无转移者,差异均有统计学意义(P<0.05)。结论:宫颈癌患者血清中Hmga1、CK19及CA125水平明显升高,并与分期、分化程度、癌细胞转移密切相关,可作为临床诊断宫颈癌及评估患者病情严重程度的辅助手段。Objective:To study the relationship between levels of serum high mobility proteina1(Hmga1),cytokeratin(CK)19 and carbohydrate antigen(CA)125 and the severity of cervical cancer to provide bases for clinical diagnosis and evaluation of the condition.Methods:The clinical data of 70 patients with cervical cancer(cervical cancer group)diagnosed in the hospital from January 2019 to June 2019 were retrospectively analyzed.The clinical data of 40 patients with cervical intraepithelial neoplasia(CIN)(precancerous lesion group)discovered during gynecologic tumor screening and 30 healthy women(control group)were collected for comparison.The levels of hmga1,CK19 and CA125 in serum of the three groups were compared,and their relationship with the severity of cervical cancer was analyzed.Results:The levels of hmga1,CK19 and CA125 in serum showed cervical cancer grouP>precancerous lesion grouP>control group(P<0.05).In cervical cancer group,there were no significant differences in levels of serum hmga1,CK19 or CA125 between patients with different tumor diameters and pathological types(P>0.05),while levels of serum hmga1,CK19 and CA125 were significantly higher in stage III^IV than in stage I^II,significantly higher in patients with moderate and poor differentiation than in patients with high differentiation,and significantly higher in patients with lymph node metastasis than in patients without(P<0.05).Conclusion:The levels of hmga1,CK19 and CA125 in serum of patients with cervical cancer are significantly increased,and are closely related to stage,differentiation and metastasis.They can be used as auxiliary means for clinical diagnosis of cervical cancer and assessment of the severity of the disease.

关 键 词：宫颈癌 高迁移率蛋白a1 细胞角蛋白19 糖类抗原125 

分 类 号：R737.33[医药卫生—肿瘤]