血浆NT-proBNP cTnI D-D水平对急性肺栓塞发病风险的评估价值  

A Value Assessment of NT ProBNP,CTnI and D-D Levels in the Risk of Acute Pulmonary Embolism

作　　者：王青松[1] 王珠秀[1] WANG Qingsong;WANG Zhuxiu(The Affiliated Hospitial of Chengde Medical College,Hebei Chengde 067000,China)

机构地区：[1]承德医学院附属医院,河北承德067000

出　　处：《河北医学》2020年第10期1720-1723,共4页Hebei Medicine

基　　金：河北省承德市科学技术研究与发展计划项目,(编号:201601A024)。

摘　　要：目的:探讨血浆N末端B型纳尿肽原(NT-proBNP)、肌钙蛋白(cTnI)、D-二聚体(D-D)水平对急性肺栓塞(APE)发病风险的评估价值。方法:对医院2017年1月至2019年1月收治的120例APE高危患者的临床资料进行回顾性分析。统计APE占比,对比发生组和未发生组患者血浆NT-proBNP、cTnI、D-D水平,分析血浆NT-proBNP、cTnI、D-D水平对APE高危是否发生APE的评估价值。结果:APE发生占比22.88%;发生组血浆NT-proBNP、cTnI、D-D水平均高于未发生组(P<0.05);血浆NT-proBNP、cTnI、D-D水平评估是否发生APE的最佳截断点为1987.38pg/mL、75.41μg/mL和5.86mg/L,三者联合评估APE发病的特异度、AUC最高。血浆NT-proBNP、cTnI、D-D水平联合评估APE发病情况的AUC与单独评估比较,差异均有统计学意义(P<0.05)。结论:APE患者血浆NT-proBNP、cTnI、D-D水平均升高,且血浆NT-proBNP、cTnI、D-D水平联合对APE的发生均具有理想的评估效能。Objective:To investigate the value of plasma N-terminal B-type natriuretic peptide(NT proBNP),Troponin(cTnI),D-Dimer(D-D)levels in the risk of acute pulmonary embolism(APE).Methods:The clinical data of 120 patients with high-risk APE admitted to the hospital from January 2017 to January 2019 were analyzed retrospectively.The proportion of APE patients was statistically analyzed.The levels of NT proBNP,cTnI and D-D were compared between the occurrence group and the non-occurrence group.The plasma NT-proBNP,cTnI,and D-D levels were analyzed to evaluate whether APE occurred in high-risk APE.Results:The patients who got APT accounted for 22.88%,and the levels of NT proBNP,cTnI and D-D in the occurrence group were higher than that in the non-occurrence group(P<0.05).Plasma NT-proBNP,cTnI,D-D levels had the best cutoff points to assess whether APE occurs,which were 1987.38pg/mL,75.41μg/mL and 5.86mg/L,and the specificity and AUC of the combination of NT proBNP,cTnI and D-D were the highest.There were significant differences between the AUC of NT proBNP,cTnI and D-D level combination assessment and those of single assessment(P<0.05).Conclusion:The levels of NT proBNP,cTnI and D-D in the plasma of APE patients are all increased,and the combination of the levels of NT proBNP,cTnI and D-D is ideal to the evaluation of the occurrence of APE.

关 键 词：急性肺栓塞 N末端B型纳尿肽原 肌钙蛋白 D-二聚体 

分 类 号：R563.5[医药卫生—呼吸系统]