肝脏瞬时弹性成像评价糖尿病肾病患者肝脏脂肪 变性和纤维化程度及其相关性分析  

Evaluation of liver steatosis and fibrosis in patients with type 2 diabetic nephropathy and their correlation by FibroTouch technique

作　　者：刘璐 苏本利[2] 张宇虹[1] LIU Lu;SU Benli;ZHANG Yuhong(Department of Ultrasound,the Second Hospital of Dalian Medical University,Liaoning 116021,China)

机构地区：[1]大连医科大学附属第二医院超声科,辽宁省大连市116021 [2]大连医科大学附属第二医院内分泌科,辽宁省大连市116021

出　　处：《临床超声医学杂志》2020年第10期781-784,共4页Journal of Clinical Ultrasound in Medicine

摘　　要：目的探讨肝脏瞬时弹性成像技术FibroTouch评价2型糖尿病肾病(DN)患者肝脏脂肪变性和肝脏纤维化程度的临床价值,分析二者的相关性。方法选取DN患者90例,根据肾小球滤过率(eGFR)将其分为3组:eGFR≥90 ml·min^-1·1.73 m^-2者为A组(30例),60 ml·min^-1·1.73 m-2≤eGFR<90 ml·min^-1·1.73 m^-2者为B组(30例),eGFR<60 ml·min^-1·1.73 m^-2者为C组(30例),同时选取30名健康志愿者为对照组。应用FibroTouch技术获得并比较各组肝脏脂肪衰减值和肝脏硬度值,分析两者相关性。结果各组肝脏脂肪衰减值和肝脏硬度值比较,A、B、C组均明显高于对照组,B、C组均高于A组,C组高于B组,差异均有统计学意义(均P<0.05)。相关性分析显示,肝脏脂肪衰减值与肝脏硬度值呈正相关(r=0.733,P<0.01)。结论应用FibroTouch技术可以准确、无创地评价DN患者的肝脏脂肪变性和纤维化程度,具有重要的临床意义。Objective To evaluate the degree of liver fibrosis and steatosis,and their correlation in patients with type 2 diabetic nephropathy(DN)by FibroTouch technique.Methods Ninety patients with type 2 diabetic nephropathy were enrolled and divided into three groups according to the level of estimate glomerular filtration rate(eGFR):eGFR≥90 ml·min^-1·1.73 m^-2 as group A(n=30),60 ml·min^-1·1.73 m^-2≤eGFR<90 ml·min^-1·1.73 m^-2 as group B(n=30)and eGFR<60 ml·min^-1·1.73 m^-2 as group C(n=30).Meanwhile,30 healthy volunteers were enrolled as control group.The fat attenuation value and the liver stiffness value of above groups were obtained by FibroTouch technique,and the correlation was analyzed.Results The fat attenuation values and the liver stiffness values of group A,B and C were significantly higher than that of control group(all P<0.05).The fat attenuation values and the liver stiffness values of group B and C were higher than those of group A(P<0.05),and group C were higher than those of group B(all P<0.05).The fat attenuation value was positively correlated with the liver stiffness value(r=0.733,P<0.01).Conclusion The degree of liver steatosis and fibrosis of DN patients can be evaluated accurately and noninvasively by FibroTouch technique with an important clinical value.

关 键 词：超声检查 瞬时弹性成像 脂肪肝 肝纤维化 糖尿病肾病 

分 类 号：R445.1[医药卫生—影像医学与核医学] R587.1[医药卫生—诊断学]