血清Tim-3 mRNA、MCP-1、IL-22、sCD30对慢性心力衰竭并发肺部感染患者的诊断价值  

Diagnostic value of serum Tim-3 mRNA,MCP-1,IL-22 and sCD30 for patients with chronic heart fail⁃ure complicated with pulmonary infection

作　　者：王春玲 孙增晋 王俊茹 毕瑞云 刘玲 尹金淑 WANG Chun-ling;SUN Zeng-jin;WANG Jun-ru;BI Rui-yun;LIU Ling;YIN Jin-shu(Department 6 of Internal Medicine,Beijing Social Welfare Hospital,Beijing 100085,China;Department of Laboratory,Beijing Social Welfare Hospital,Beijing 100085,China;Department of Respiration,Beijing Century Temple Hospital Affiliated to Capital Medical University,Beijing 100038,China)

机构地区：[1]北京市社会福利医院六病区,北京100085 [2]北京市社会福利医院检验科,北京100085 [3]首都医科大学附属北京世纪坛医院呼吸科,北京100038

出　　处：《岭南心血管病杂志》2020年第5期574-579,共6页South China Journal of Cardiovascular Diseases

基　　金：北京市科学技术委员会课题(项目编号:Z161100000516006)。

摘　　要：目的探讨血清人T细胞免疫球蛋白黏蛋白分子3(T cell immunoglobulin mucin molecule 3,Tim-3)mRNA、人单核细胞趋化蛋白-1(monocyte chemoattractant protein-1,MCP-1)、白细胞介素-22(interleukin-22,IL-22)、人可溶性CD30(soluble CD30,sCD30)对慢性心力衰竭并发肺部感染患者的诊断价值。方法选取2016年10月到2019年1月北京市社会福利医院收治的老年慢性心力衰竭患者144例作为研究对象,依据是否发生肺部感染将患者分为对照组72例和肺部感染组72例,另选72名健康体检者为健康组。抽血检测3组人群血清中Tim-3mRNA、MCP-1、IL-22、sCD30浓度并进行比较。结果肺部感染组患者血清Tim-3 mRNA、MCP-1、IL-22、sCD30浓度高于对照组,对照组高于健康组,差异有统计学意义(P<0.05)。慢性心力衰竭并发肺部感染患者血清MCP-1、IL-22、sCD30、Tim-3 mRNA之间互为正相关,并且随着肺感染程度分级和纽约心脏协会心功能分级的升高而升高,不同分级间比较差异具有统计学意义(P<0.05)。Tim-3 mRNA、MCP-1、IL-22、sCD30诊断肺部感染的受试者工作特征曲线(receiver operating characteristic curve,ROC)的曲线下面积(area under curve,AUC)均接近于0.9,说明诊断准确性较高。结论Tim-3mRNA、MCP-1、IL-22、sCD30可能是慢性心力衰竭患者是否肺部感染的诊断标志物,监测其浓度变化对患者病情评估具有重要临床意义。Objectives To investigate the diagnostic values of serum human T cell immunoglobulin mucin molecule 3(Tim-3)mRNA,human monocyte chemoattractant protein-1(MCP-1),interleukin-22(IL-22)and human soluble CD30(sCD30)for patients with chronic heart failure complicated with pulmonary infection.Methods Totally 144 elderly patients with chronic heart failure admitted to Beijing Social Welfare Hospital from October 2016 to January 2019 were selected.The patients were divided into control group(n=72)and pulmonary infection group(n=72)according to whether pulmonary infection occurred.Another 72 healthy persons were selected as healthy group.Serum concentrations of Tim-3 mRNA,MCP-1,IL-22 and sCD30 among the three groups were detected and compared.Results Serum concentrations of Tim-3 mRNA,MCP-1,IL-22 and sCD30 in lung infection group were significantly higher than those in control group,and those in control group were significantly higher than those in healthy group(P<0.05).Serum concentrations of MCP-1,IL-22,Tim-3 mRNA and sCD30 in patients with chronic heart failure complicated with pulmonary infection positively correlated with each other,and increased with the increasing of grade of pulmonary infection and New York Heart Association(NYHA)cardiac function classification.The difference between different grades was statistically significant(P<0.05).The areas under the receiver operating characteristic curve(ROC)for the diagnosis of pulmonary infection by Tim-3 mRNA,MCP-1,IL-22 and sCD30 were all close to 0.9,indicating a high diagnostic accuracy.Conclusions Tim-3 mRNA,MCP-1,IL-22 and sCD30 may be the diagnostic markers of pulmonary infection in patients with chronic heart failure,monitoring the concentration changes of them may have im⁃portant clinical significance in evaluating patients'condition.

关 键 词：心力衰竭 肺部感染 T细胞免疫球蛋白黏蛋白分子3mRNA 人单核细胞趋化蛋白-1 白细胞介素-22 可溶性CD30 

分 类 号：R541.6[医药卫生—心血管疾病]