喜炎平注射液联合阿奇霉素治疗小儿肺炎支原体肺炎的临床研究  

Clinical study of Xiyanping injection combined with azithromycin in the treatment of Mycoplasma pneumoniae pneumonia in children

作　　者：吴昊 WU Hao(Department of Pharmacy,Dandong Women’s and Children’s Hospital,Dandong 118000,China)

机构地区：[1]丹东市妇女儿童医院药剂科,118000

出　　处：《中国现代药物应用》2020年第20期115-116,共2页Chinese Journal of Modern Drug Application

摘　　要：目的评价小儿肺炎支原体肺炎患儿采取喜炎平注射液联合阿奇霉素治疗的预后效果。方法 100例小儿肺炎支原体肺炎患儿,根据治疗方案不同分为对照组与观察组,各50例。对照组采取阿奇霉素治疗,观察组在对照组基础上联合喜炎平注射液治疗。比较两组患儿治疗效果、症状及体征改善时间、血清细胞因子水平。结果观察组治疗总有效率为98.0%,高于对照组的84.0%,差异有统计学意义(χ^2=5.9829, P=0.0144<0.05)。观察组退热时间、咳嗽消失时间、肺啰音消失时间、X线胸片吸收时间、住院时间分别为(2.5±1.0)、(4.2±1.3)、(5.0±1.2)、(6.0±1.2)、(7.5±1.0)d,均短于对照组的(3.8±1.5)、(6.0±1.5)、(6.0±1.5)、(7.6±1.3)、(8.5±1.0)d,差异有统计学意义(P<0.05);观察组白介素细胞-6(IL-6)、白介素细胞-8(IL-8)、肿瘤坏死因子-α(TNF-α)水平分别为(19.0±10.0)、(8.0±5.0)、(25±8.0)ng/L,均低于对照组的(27.0±12.0)、(13.0±5.0)、(36.0±10.0)ng/L,差异有统计学意义(P<0.05)。结论针对小儿肺炎支原体肺炎患儿,对比单一阿奇霉素治疗,喜炎平注射液联合阿奇霉素治疗提升了临床疗效、加速了小儿症状体征改善,整体预后情况良好。Objective To evaluate the prognostic effect of Xiyanping injection combined with azithromycin in children with Mycoplasma pneumoniae pneumonia.Methods A total of 100 children with Mycoplasma pneumoniae pneumonia were divided into control group and observation group according to different treatment regimens,with 50 cases in each group.The control group was treated with azithromycin,and the observation group was treated with Xiyanping injection on the basis of the control group.The therapeutic effect,improvement time of symptom and signs and serum cytokine levels were compared between the two groups.Results The total effective rate of treatment of the observation group was 98.0%,which was higher than 84.0%of the control group,and the difference was statistically significant(χ^2=5.9829,P=0.0144<0.05).The antipyretic time,cough disappearance time,lung rale disappearance time,chest X-ray absorption time,hospitalization time of the observation group were(2.5±1.0),(4.2±1.3),(5.0±1.2),(6.0±1.2)and(7.5±1.0)d,which were shorter than(3.8±1.5),(6.0±1.5),(6.0±1.5),(7.6±1.3)and(8.5±1.0)d of the control group,and the difference was statistically significant(P<0.05).The interleukin-6(IL-6),Interleukin-8(IL-8),tumor necrosis factor-α(TNF-α)of the observation group were(19.0±10.0),(8.0±5.0)and(25±8.0)ng/L,which were lower than(27.0±12.0),(13.0±5.0)and(36±10.0)ng/L of the control group,and the difference was statistically significant(P<0.05).Conclusion Compared with single azithromycin treatment,the combination of Xiyanping injection can improve the clinical effect,accelerate the improvement of symptoms and signs of children with Mycoplasma pneumonia pneumonia,and the overall prognosis is good.

关 键 词：喜炎平注射液 阿奇霉素 治疗效果 

分 类 号：R725.6[医药卫生—儿科]