CC趋化因子与心肌梗死的研究进展  

The Roles of CC Chemokine in Myocardial Infarction

作　　者：冯聚玲 王真真 赵磊[4] 陈乃宏 FENG Ju-Ling;WANG Zhen-Zhen;ZHAO Lei;CHEN Nai-Hong(College of Pharmacy,Hunan University of Chinese Medicine,Changsha 410208,China;Institute of Materia Medica,Neuroscience Center,Peking Union Medical College&Chinese Academy of Medical Sciences,Beijing 100050,China;Research Laboratory of Translational Medicine,Hengyang Medical College,University of South China,Hengyang 421001,China;Department of Gastrointestinal Surgery,The First Affiliated Hospital,University of South China,Hengyang 421001,China)

机构地区：[1]湖南省中医药大学药学院,长沙410208 [2]中国医学科学院-北京协和医学院药物研究所神经科学中心,北京100050 [3]南华大学衡阳医学院转化医学研究室,衡阳421001 [4]南华大学附属第一医院胃肠外科,衡阳421001

出　　处：《生物化学与生物物理进展》2020年第10期1046-1055,共10页Progress In Biochemistry and Biophysics

基　　金：国家自然科学基金(81900488);湖南中医药大学一流学科项目(201803);湖南省中药饮片标准化及功能工程技术研究中心项目(2016TP2008);湖南省中药饮片标准化及功能工程技术研究中心开放基金项目(BG201701,0101003004);湖南省自然科学基金(2019JJ50549)资助。

摘　　要：CC类趋化因子亚家族是趋化因子家族中成员最多、研究最广泛的一大类细胞因子,其主要功能是参与炎症细胞激活、迁移、黏附等病理生理过程.大量研究表明,CC类趋化因子亚家族成员参与了心肌梗死后病理过程的各个阶段.其中研究最为深入的是单核细胞趋化蛋白1(monocyte chemoattractant protein-1,MCP-1)及其受体CC趋化因子受体2(CC chemokine receptor 2,CCR2).MCP-1和CCR2在心肌梗死后炎症期、增殖期及疤痕愈合期都发挥了重要作用从而影响梗死后心室重构.近年来,CC类趋化因子亚家族其他成员亦被逐渐揭示参与了心肌梗死的发展.本文结合以往大量文献,就CC类趋化因子亚家族在心肌梗死各个阶段中的作用,尤其是梗死后各期对于心室重构的影响进行综述,以期为今后的CC趋化因子研究提供方向,为相关疾病的预防和治疗研究提示潜在的药物靶点.The CC chemokines is the largest and most widely studied group of chemokines,which play a critical role in inflammatory leukocyte locomotion,trafficking and adhesion.The chemokine CC subfamily are involed in the pathogenesis of myocardial infarction.Monocyte chemoattractant protein-1(MCP-1)and its receptor CC Chemokine receptor 2(CCR2),as most studied chemokine,plays an important role in post-infarction inflammation,proliferation and scar formation,thus affecting ventricular remodeling after myocardial infarction.In recent years,other members of the CC chemokines have been gradually revealed to be involved in the development of myocardial infarction.This article reviews the role of CC chemokines in various stages of myocardial infarction,especially the effects on ventricular remodeling after myocardial infarction,in order to provide direction for future experimental research and novel strategies in the treatment of patients with myocardial infarction disease.

关 键 词：CC类趋化因子亚家族 心肌梗死 炎症 心室重构 

分 类 号：Q7[生物学—分子生物学] R5[医药卫生—内科学]