通过光学相干断层扫描图像进行自动视网膜分割评估黄斑水肿的投影面积  

Projection Area Evaluation of Macular Edema by Optical Coherence Tomography Images With Automatic Retinal Segmentation

作　　者：张章 唐艳红 曾兴晖 熊红莲 曾亚光[1] 韩定安[1] ZHANG Zhang;TANG Yan-Hong;ZENG Xing-Hui;XIONG Hong-Lian;ZENG Ya-Guang;HAN Ding-An(School of Physics and Optoelectronic Engineering,Foshan University,Foshan 528000,China)

机构地区：[1]佛山科学技术学院物理与光电工程学院,佛山528000

出　　处：《生物化学与生物物理进展》2020年第10期1097-1108,共12页Progress In Biochemistry and Biophysics

基　　金：国家自然科学基金(61605026,61771139,81601534,61705036,61805038);广东省自然科学基金(2017A030313386);佛山科学技术学院高层次建设与科研项目(CGG07141);佛山科学技术学院高层次人才科研启动项目(gg040988)资助.

摘　　要：本文提出一种自动视网膜分割方法,以评估光学相干断层扫描(OCT)图像中黄斑水肿(ME)在视网膜特定层上的投影面积.首先使用基于权重矩阵的优化最短路径最快算法对10个视网膜层边界进行分割,这有效降低了算法对血管阴影的敏感性.然而,ME的存在将导致水肿区域的分割不准确.因此,使用强度阈值方法提取每个OCT图像中的水肿区域,并将该区域中的值设置为零,并确保获得的分割边界可以自动穿过而不是绕过水肿区域.同时使用最小值投影来计算ME在不同层的投影面积.为了测试该方法,使用了从Topcon OCT机器收集的数据.在轴向和B扫描方向上测得的黄斑区域分辨率分别为11.7μm和46.8μm.与手动分割相比,视网膜层边界分割的平均绝对误差和标准偏差为(4.5±3.2)μm.因此,所提出的方法为评估水肿提供了一种自动、无创和定量的工具.In this paper,we propose an automatic retinal segmentation method to evaluate the projection area of macular edema(ME)on specific layers of the retina in optical coherence tomography(OCT)images.Ten retinal layer boundaries are segmented using an optimized Shortest-Path Faster Algorithm based on weight matrices first,which effectively reduces the algorithm’s sensitivity to vascular shadows.However,the presence of ME will result in an inaccurate segmentation of the edema area.Therefore,we use the intensity threshold method to extract the edematous area in each OCT image,set the values in this area to zero,and ensure that the obtained segmented boundary can automatically cross rather than bypass the edematous area.We use the minimum projection method to calculate the projected area of ME at different layers.To test our method,we used data collected from Topcon’s OCT machine.The measured macular area resolution in the axial and B-scan directions was 11.7 microns and 46.8 microns,respectively.The mean absolute and standard deviation difference values of the retinal layer boundary segmentations were 4.5±3.2 microns compared to manual segmentation.The proposed method,thus,provides an automatic,noninvasive,and quantitative tool for the evaluation of edema.

关 键 词：光学相干断层扫描 黄斑水肿 视网膜分割 投影面积评估 

分 类 号：R445[医药卫生—影像医学与核医学]