拉贝洛尔联合尼莫地平治疗妊娠期高血压疾病及对PAPPA、PLGF、sFIt 1影响  

The effect of rabeprolol combined with nimodipine for treating women with pregnancy induced hypertension and its influence on the levels of PAPPA,PLGF,and sfit 1

作　　者：徐吉雯[1] 叶婧[1] 乔允 杭瑛[1] XU Jiwen;YE Qian;QIAO Yun;HANG Ying(Renji Hospital,School of Medicine,Shanghai Jiaotong University,200127)

机构地区：[1]上海交通大学医学院附属仁济医院,200127

出　　处：《中国计划生育学杂志》2020年第9期1388-1391,共4页Chinese Journal of Family Planning

摘　　要：目的:研究拉贝洛尔联合尼莫地平治疗妊娠期高血压疗效及对血清妊娠关联血浆蛋白A(PAPPA)、胎盘生长因子(PLGF)、人可溶性血管内皮生长因子1(sFIt 1)影响。方法:收集2016年2月-2018年2月本院治疗的妊娠期高血压患者82例,按随机数字表法分为观察组和对照组各41例,两组均采取尼莫地平治疗,观察组同时联合采用拉贝洛尔治疗,治疗4周。比较血压控制情况、血清PAPPA、PLGF、sFIt 1水平、妊娠结局、分娩方式及不良反应。结果:治疗后,两组收缩压和舒张压均有明显改善,且观察组改善程度优于对照组;两组血清PAPPA水平下降,PLGF、sFIt 1上升,且观察组改善幅度高于对照组;观察组顺产率(85.4%)高于对照组(65.9%),不良妊娠结局发生率(7.3%)低于对照组(46.3%)(均P<0.05)。结论:拉贝洛尔联合尼莫地平治疗妊娠期高血压孕妇可提高疗效,通过对患者血清PAPPA水平下调,PLGF、sFIt 1水平上调发挥药效作用。Objective:To study the effect of rabeprolol combined with nimodipine for treating pregnant women with pregnancy induced hypertension,and to study its influence on their levels of serum pregnancy associated plasma protein A(PAPPA),placental growth factor(PLGF),FIT 1.Methods:82 women with pregnancy induced hypertension were collected and divided into observation group and control group(41 women in each group)according to the random number table from February 2016 to February 2018.The women in the control group were treated with nimodipine for 4 weeks,while the women in the observation group were treated with rabeprolol combined with nimodipine during the same time for 4 weeks.The blood pressure control situation,the levels of serum PAPPA,PLGF,and FIT 1,pregnancy outcomes,delivery mode,and adverse reactions rate of women were compared between the two groups.Results:After treatment,systolic blood pressure and diastolic blood pressure values had improved significantly,and the improvement degree of women in the observation group was significant better than that of women in the control group.The serum PAPPA level of women in the two groups had decreased significantly,PLGF and FIT 1 levels of women in the two groups had increased significantly,and the improvement degree of women in the observation group was significant better than that of women in the control group.In the observation group,the rate of natural childbirth(85.4%)of women in the observation group was significant higher than that(65.9%)of women in the control group,but the incidence of adverse pregnancy outcome(7.3%)of women in the observation group was significant lower than that(46.3%)of women in the control group(all P<0.05).Conclusion:Abeprolol combined with nimodipine for treating pregnant women with pregnancy induced hypertension can increase the efficacy,which play a pharmacodynamic role by down regulating serum PAPPA level and up regulating the levels of PLGF and FIT 1.

关 键 词：妊娠期高血压 拉贝洛尔 尼莫地平 妊娠关联血浆蛋白A 胎盘生长因子 人可溶性血管内皮生长因子1 疗效 

分 类 号：R714.246[医药卫生—妇产科学]