Materials design and sensing mechanism of novel calix[6]arene composite for sensitively detecting amine drugs  

作　　者：Nana Liu Yu Fan Zhiheng Ma Haixia Lin Jiaqiang Xu 

机构地区：[1]NEST Lab,Department of Chemistry,College of Sciences.Shanghai University,Shanghai 200444,China [2]Department of Physics,College of Science,Shanghai University,Shanghai 200444,China

出　　处：《Chinese Chemical Letters》2020年第8期2129-2132,共4页中国化学快报（英文版）

基　　金：the support of National Natural Science Foundation of China(No.61527818);the Shanghai Municipal Education Commission(No.Peak Discipline Construction Program)。

摘　　要：In order to improve the co nvenie nce and sensitivity of amphetamines drug testing and reduce the threat of drugs to humans,we have designed a QCM gas sensor to detect amine-containing drugs.The sensing material is designed based on the chemical nature of amine drugs.The sensing mechanism is derived from a reve rsible Schiff base interaction between the amino group of the drug and the carbonyl group of the novel calix[6]arene derivatives as well as the hydrogen bond interaction between amino group and hydroxyl.The new composite material was well characterized by different analytical techniques including 1 H nuclear magnetic resonance(1 H-NMR),fourier transform infrared spectroscopy(FT-IR),scanning electro nic microscopy(SEM),transmission electron microscope(TEM),Raman spectra,powder X-ray diffraction,etc.The sensing experiments were conducted by coating the composite onto quartz crystal microbalance(QCM)transducers.The experimental results indicated that the novel calixarene derivatives and their GO complexes based on the design have excellent selectivity,high sensitivity and repeatability toβ-phenylethylamine.

关 键 词：Drug detection arene derivative GO complexes Quartz crystal microbalance sensor Schiff base interaction 

分 类 号：TB332[一般工业技术—材料科学与工程] TP212[自动化与计算机技术—检测技术与自动化装置] TQ460.72[自动化与计算机技术—控制科学与工程]