体外实验用人工皮肤模型的研究简介  

Introduction on artificial skin models for in vitro test

作　　者：岑月眉 闻萍 李久盛 曾祥琼 CEN Yue-mei;WEN Ping;LI Jiu-sheng;ZENG Xiang-qiong(Advanced Lubrication Materials Laboratory,Shanghai Advanced Research Instituce,Chinese Academy of Sciences,University of Chinese Academy of Sciences,Shanghai 201210,China;University of Chinese Academy of Sciences,Beijing 100049,China;Plinberry Biopharmaceutical Co.Ltd.,Shanghai 201203,China)

机构地区：[1]中国科学院大学中国科学院上海高等研究院先进润滑材料实验室,上海201210 [2]中国科学院大学,北京100049 [3]普霖贝利生物有限公司,上海201203

出　　处：《药物分析杂志》2020年第9期1543-1549,共7页Chinese Journal of Pharmaceutical Analysis

基　　金：上海市自然科学基金项目(17ZR1442100)。

摘　　要：体外试验是研究经皮药物制剂、化妆品等活性成分的渗透动力学,从而预测活性成分经过人体皮肤渗透特性的重要手段。体外试验研究过程中,渗透介质的选择是人工皮肤膜扩散试验恰当反应活性成分经皮渗透特性的关键。国内外研究报道的渗透介质有动物皮肤、离体人体皮肤和人工皮肤膜型。本文对目前体外试验研究的渗透介质的使用情况,及活性成分体外实验研究与经皮特性的相关性进行了介绍,对介质的组成和特性进行了对比,并对未来人工皮肤模型的设计与发展进行了展望。In vitro test is an important method to study the permeation kinetics of active ingredients,so as to predict the transdermal properties of active ingredients through human skin.During the in vitro test,selecting appropriate permeable medium is a key factor for reflection on percutaneous property.Animal skin,ex vivo human skin and artificial skin model have been reported in home and abroad.In this paper,the use of permeable medium in current percutaneous diffusion test,the correlation between in vitro experimental studies of active substances and percutaneous properties,and the composition and properties of the medium are introduced and compared.Finally,the future development of artificial skin model is proposed.

关 键 词：体外试验 渗透介质 活性成分 经皮传导 人工皮肤膜型 

分 类 号：R917[医药卫生—药物分析学]