苏铁的化学成分和活性成分的研究进展  

Research Progress on the Chemical Constituents and Active Constituents of Cycas revolute Thunb

作　　者：刘颖杰[1,2] 黄玉玲 许颖 付纪源[1] LIU Ying-jie;HUANG Yu-ling;XU Ying;FU Ji-yuan(Engineering Research Center of Natural Anticancer Drugs,Ministry of Education,College of Pharmacy,Harbin University of Commerce,Harbin 150076,China;Engineering Research Center for Medicine,College of Pharmacy,Harbin University of Commerce,Harbin 150076,China)

机构地区：[1]哈尔滨商业大学国家教育部抗肿瘤天然药物工程研究中心,哈尔滨150076 [2]哈尔滨商业大学药学院药物工程技术研究中心,哈尔滨150076

出　　处：《中国药学杂志》2020年第18期1492-1498,共7页Chinese Pharmaceutical Journal

基　　金：黑龙江省自然基金联合引导项目资助(LH2020H068,LH2020H070);黑龙江省自然科学基金项目资助(H2017001);黑龙江省青年创新人才项目资助(UNPYSCT-2018139);哈尔滨商业大学创新人才项目资助(2019CX38)。

摘　　要：苏铁是我国的一级保护植物,具有很高的药用价值,早在清朝时期就已记载开始利用苏铁来治疗疾病。早期对苏铁的研究主要集中于分类、保护和育种,近几年来,人们开始研究苏铁植物的主要化学成分、化学结构和药理作用,为苏铁植物的进一步开发利用打下了坚实的理论基础。苏铁中主要含有能用于肿瘤治疗的双黄酮类化合物,目前在苏铁植物中研究发现的双黄酮化合物大多是穗花杉双黄酮和扁柏双黄酮的衍生物。苏铁提取物除了具有抗肿瘤活性之外,还具有抑菌、抗氧化和增强免疫力等药理活性。Cycas revolute Thunb is a first class protected plant in China and has high medicinal value.As early as the Qing dynasty,it was recorded that Cycas was use to treat disease.Early research on Cycas mainly focused on classification,protection and breeding.In recent years,people began to study the main chemical constituents,chemical structure and pharmacological effects of Cycas,which laid a solid theoretical foundation for the further development and utilization of Cycas.At present,most of amentoflavone derivatives and hinokiflavone derivatives found in Cycas have the therapeutic effect on tumor.In addition to the antitumor activity,the extracts of Cycas also have antibacterial,antioxidant and immunological activities.

关 键 词：苏铁 化学成分 药理活性 双黄酮 苏铁苷 

分 类 号：R282[医药卫生—中药学]