成骨细胞吞噬内化金黄色葡萄球菌在骨髓炎发病机制中的作用  

Involvement of phagocytosis and internalization of Staphylococcus aureus by osteoblasts in the pathogenesis of osteomyelitis

作　　者：蔡渊卿 方心俞[1] 张翀景 张超凡[1] 黄子达[1] 李文波[1] 杨滨[2] 张文明[1] CAI Yuanqing;FANG Xinyu;ZHANG Chongjing;ZHANG Chaofan;HUANG Zida;LI Wenbo;YANG Bin;ZHANG Wenming(Department of Orthopaedics,First Affiliated Hospital of Fujian Medical University,Fuzhou 350005,China;Department of Laboratory Medicine,First Affiliated Hospital of Fujian Medical University,Fuzhou 350005,China)

机构地区：[1]福建医科大学附属第一医院骨科,福州350005 [2]福建医科大学附属第一医院检验科,福州350005

出　　处：《中华骨与关节外科杂志》2020年第8期681-687,共7页Chinese Journal of Bone and Joint Surgery

基　　金：国家自然科学基金面上项目(81772251);福建省自然科学基金高校产学合作项目(2018Y4003);福建省自然科学基金对外合作项目(2018I0006)。

摘　　要：成骨细胞与破骨细胞存在于骨组织中,负责骨细胞外基质的形成与吸收,共同维持骨代谢的平衡。近年研究发现,这些骨组织中的细胞与免疫细胞通过多种通路存在相互作用,从而衍生出了一门新学科——"骨免疫学",其目的在于研究骨骼系统与免疫系统之间相互作用的分子机制。其中成骨细胞发挥了重要作用。金黄色葡萄球菌是骨髓炎中最常见的致病菌,可以粘附于成骨细胞表面并被内化,逃避宿主免疫系统的杀灭,并发生表型的转变(如小菌落变异等),而当细胞死亡后这些细菌被释放,再次感染其他细胞,形成新的感染,导致骨髓炎临床治疗效果较差且迁延不愈。对金黄色葡萄球菌侵袭成骨细胞这一过程进行深入的了解和研究将有助于开发治疗骨髓炎的新靶标。本文就成骨细胞吞噬内化金黄色葡萄球菌在骨髓炎发病中的作用做一综述。Osteoblasts and osteoclasts, which are responsible for the formation and absorption of bone extracellular matrix, are the key to maintain the balance of bone metabolism. In recent years, it has been showed that skeletal system could interact with immune system via various pathways, which leads to a novel inter-discipline "osteoimmunology ". Its purpose is to study the molecular mechanism of the interaction between the skeletal and immune system, in which osteoblasts play an important role. Staphylococcus aureus is the most common pathogen in osteomyelitis, it can adhere to the surface of osteoblasts and be internalized to escape from the attack of immune system, and undergo phenotypic switch(such as small colony variation). After cell death, these intracellular bacteria could be released and cause new infections, resulting in poor clinical outcome. Thus, it is of great significance to understand and study of the process of Staphylococcus aureus invading osteoblasts thoroughly to develop new therapeutic targets. This article reviewed the role of phagocytosis and internalization of Staphylococcus aureus by osteoblasts in the pathogenesis of osteomyelitis.

关 键 词：成骨细胞 金黄色葡萄球菌 骨髓炎 溶酶体 小菌落变异 

分 类 号：R681.2[医药卫生—骨科学]