他汀联合尼可地尔对急性冠脉综合征患者PCI术后缺血再灌注损伤的作用研究  

Statins Combined with Nicotil after PCI in Patients with Acute Coronary Syndrome Study on the Role of Ischemia-Reperfusion Injury

作　　者：蒋芳勇[1] 陈慧生[1] 黄山松 Jiang Fangyong(Department of cardiology,Liuzhou people’s hospital,Liuzhou Guangxi 545006)

机构地区：[1]柳州市人民医院心内科,广西柳州545006

出　　处：《黑龙江医药》2020年第4期744-746,共3页Heilongjiang Medicine journal

基　　金：柳州市科技计划项目(编号:2019BJ10610)。

摘　　要：目的:探索阿托伐他汀联合尼可地尔对急性冠脉综合征患者PCI术后缺血再灌注损伤的作用。方法:入选需急诊行PCI的患者90例,其中联合治疗组30例患者给予阿托伐他汀联合尼可地尔治疗,治疗组30例患者给予阿托伐他汀治疗,对照组30例则进行PCI术治疗。观察患者超氧化物歧化酶(SOD)的活性、丙二醛(MDA)水平、脑钠肽前体(NT-pro-BNP)及超敏C反应蛋白(hs-CRP)的变化与心脏不良事件(MACEs)发生情况。结果:联合治疗组及治疗组SOD活性明显高于对照组,其中联合治疗组高于治疗组;联合治疗组及治疗组MDA活性明显低于对照组,其中联合治疗组低于治疗组。术后2小时联合治疗组及治疗组的hs-CRP及NT-pro-BNP水平明显低于对照组,其中联合治疗组低于治疗组。在6个月的随访中,三组的MACEs发生率相比无统计学差异。结论:PCI术前口服阿托伐他汀联合尼可地尔较单独应用阿托伐他汀对减少PCI术后的缺血再灌注损伤效果更为显著,有助于减轻患者全身炎症反应,改善心功能。Objective:To explore the effect of atorvastatin combined with nicotil on ischemic reperfusion injury after PCI in patients with acute coronary syndrome.Methods:a total of 90 patients who needed emergency PCI were enrolled,including 30 patients in the combination group who were treated with atorvastatin and nicotil,30 patients in the treatment group who were treated with atorvastatin,and 30 patients in the control group who were treated with PCI.The activity of superoxide dismutase(SOD),malondialdehyde(MDA),the changes of brain natriuretic peptide precursor(nt-pro-bnp)and hypersensitive c-reactive protein(hs-crp)and the occurrence of cardiac adverse events(MACEs)were observed.Results:SOD activity in the combined treatment group and the treatment group was significantly higher than that in the control group,and the combined treatment group was significantly higher than that in the treatment group.The MDA activity of the combined treatment group and the treatment group was significantly lower than that of the control group,among which the combined treatment group was lower than the treatment group.The hs-crp and nt-pro-bnp levels of the combined treatment group and the treatment group were significantly lower than those of the control group 2 hours after surgery,among which the combined treatment group was lower than the treatment group.There was no statistically significant difference in the incidence of MACEs between the three groups at 6 months of follow-up.Conclusion:oral atorvastatin combined with nicotil before PCI has a more significant effect on reducing ischemia/reperfusion injury after PCI than atorvastatin alone,which helps to reduce systemic inflammatory response and improve cardiac function.

关 键 词：阿托伐他汀 尼可地尔 急性冠脉综合征 经皮冠状动脉介入 缺血再灌注损伤 

分 类 号：R543.3[医药卫生—心血管疾病]