连续肾脏替代疗法在颅脑损伤合并严重低钠血症治疗的临床研究  

Clinical Study of Continuous Renal Replacement Therapy in the Treatment of Craniocerebral Injury Complicated with Severe Hyponatremia

作　　者：黄佳星 桂玉成 王美 江柳 Huang Jiaxing(Department of Critical Care Medicine,Qingxi Hospital,Dongguan Guangdong 523660)

机构地区：[1]东莞市清溪医院重症医学科,广东东莞523660

出　　处：《黑龙江医药》2020年第4期749-752,共4页Heilongjiang Medicine journal

基　　金：东莞市医疗卫生一般项目(编号:201950715015032)。

摘　　要：目的:分析连续肾脏替代疗法(CRRT)治疗颅脑损伤合并严重低钠血症的临床效果。方法:选择2018年6月至2019年6月我院40例颅脑损伤合并严重低钠血症的患者作为研究对象,随机分为实验组和对照组,各20例。以格拉斯哥昏迷评分法(GCS)、急性生理与慢性健康评分(APACHEⅡ)、死亡率作为终点指标对治疗效果进行评价。结果:实验组和对照组经不同的治疗方法后,实验组GCS评分高于对照组、APACHEⅡ评分、病死率均低于对照组(P<0.05);实验组经CRRT治疗后血钠浓度明显上升,且患者生存率优于对照组。结论:CRRT治疗颅脑损伤合并严重低钠血症的患者,可以有效纠正内环境紊乱,改善患者脑水肿及预后,其效果及安全性均优于传统治疗方法。Objective:To analyze the clinical effect of continuous renal replacement therapy(CRRT)in the treatment of craniocerebral injury complicated with severe hyponatremia.Methods:Forty patients with craniocerebral injury and severe hyponatremia in our hospital from June 2019 to June 2020 were randomly divided into experimental group and control group,with 20 cases in each group.Glasgow Coma Score(GCS),Acute Physiological and Chronic Health Score(APACHEⅡ),and Mortality were used as endpoint indicators to evaluate the therapeutic effect.Results:After different treatment methods,the GCS score of the experimental group was higher than that of the control group,APACHEⅡ score and mortality rate were lower than those of the control group(P<0.05);the serum sodium concentration of the experimental group increased significantly after CRRT treatment,and the survival rate of the patients was better than that of the control group.Conclusion:CRRT can effectively correct internal environment disorder and improve brain edema and prognosis in patients with craniocerebral injury complicated with severe hyponatremia.Its effect and safety are superior to those of traditional therapy.

关 键 词：CRRT 颅脑损伤 低钠血症 临床研究 

分 类 号：R651.15[医药卫生—外科学]