针刺足临泣对偏头痛低频振荡振幅的影响  

Study on the Influence of Acupuncture Zulinqi(GB41)on the Amplitude of Low Frequency Oscillation of Migraine

作　　者：宁艳哲 郑入文[3] 吕亚楠 付彩红 刘宏伟 任毅[4] NING Yanzhe;ZHENG Ruwen;LYU Yanan;FU Caihong;LIU Hongwei;REN Yi(Schizophrenia Institute,Beijing Institute of Critical Cerebropathy,Beijing Key Laboratory of Diagnosis and Treatment of Mental Diseases,Beijing Anding Hospital,Capital Medical University,Beijing 100088,China;Advanced Innovation Center for Human Brain Protection,Capital Medical University,Beijing 100068,China;Department of Acupuncture,Dongfang Hospital of Beijing University of Chinese Medicine,Beijing 100078,China;Department of Neurology,Dongzhimen Hospital of Beijing University of Chinese Medicine,Beijing 100700,China;Department of Cerebropathy,Beijing Shunyi Hospital of Chinese Medicine,Beijing 101300,China)

机构地区：[1]首都医科大学附属北京安定医院,北京重大脑疾病研究院精神分裂症研究所,精神疾病诊断与治疗北京市重点实验室,北京100088 [2]首都医科大学人脑保护高精尖创新中心,北京100069 [3]北京中医药大学东方医院针灸科,北京100078 [4]北京中医药大学东直门医院神经内科,北京100070 [5]北京中医医院顺义医院脑病科,北京101300

出　　处：《世界中医药》2020年第20期3131-3137,共7页World Chinese Medicine

基　　金：北京市高校青年英才计划项目(YETP0823);北京市优秀人才培养资助项目(2018000021469G292);北京中医药科技发展基金青年项目(QN2018-24,QN2018-27);北京中医药大学自主课题青年教师项目(2017-JYB-JS-072);北京中医药大学东直门医院“青苗人才”项目(DZMYS-201605)。

摘　　要：目的:应用功能磁共振明确针刺足临泣对无先兆偏头痛脑功能区域低频振荡振幅的特征性影响。方法:选取2015年1月至2016年2月北京中医药大学东直门医院神经内科和北京中医药大学东方医院针灸科门诊就诊的无先兆偏头痛患者19例作为研究对象,在针刺前后进行静息态功能磁共振成像,匹配的18例健康受试者进行一次无针刺的功能磁共振扫描作为对照。分析偏头痛患者和正常受试者脑功能区的低频振荡振幅值差异以及患者针刺前后低频振荡振幅值的变化。结果:与健康对照组比较,无先兆偏头痛患者低频振荡振幅值显著增强的脑区为海马、海马旁回、右侧颞上回等脑区,显著减弱的脑区为左侧楔叶、顶上回等脑区;与针刺前比较,针刺后低频振荡振幅值显著增强的脑区为右侧中央前回和中央后回,显著减弱的脑区为右侧楔前叶、额中回等脑区;与健康对照组比较,无先兆偏头痛患者针刺足临泣穴后低频振荡振幅值显著增强的脑区为右侧的中央前回、中央后回等脑区,显著减弱的脑区为左侧楔叶、楔前叶等脑区。结论:针刺足临泣穴对无先兆偏头痛多个脑区的功能活动异常的起特征性调节作用,这可能为针刺干预的疗效机制提供功能影像学支持。Objective:To clarify the characteristic effect of acupuncture Zulinqi(GB41)on the low-frequency oscillation amplitude of brain function in migraine without aura by using functional magnetic resonance.Methods:From January 2015 to February 2016,a total of 19 patients with migraine without aura who were admitted to the Department of Neurology,Dongzhimen Hospital of Beijing University of Chinese Medicine and the Department of Acupuncture and Moxibustion of Dongzhimen Hospital of Beijing University of Chinese Medicine were selected as the research objects.State functional magnetic resonance imaging matched 18 healthy subjects undergoing a needle-free functional magnetic resonance scan as a control.The differences in the amplitude of low-frequency oscillations in brain function areas between migraine patients and normal subjects and the changes in the amplitude of low-frequency oscillations before and after acupuncture were compared and analyzed.Results:Compared with the healthy control group,the brain regions with significantly increased low-frequency oscillation amplitude in migraine patients without aura were the hippocampus,parahippocampal gyrus,and right superior temporal gyrus,while the significantly weakened brain regions were the left cuneiform lobe and supratopia back to the other brain areas;compared with before acupuncture,the brain areas where the amplitude of low-frequency oscillations are significantly increased after acupuncture are the right central anterior and posterior gyrus,and the brain areas that are significantly weakened are the right precuneus,middle frontal gyrus,etc.and in other brain area.Compared with the healthy control group,the brain areas in which the amplitude of low-frequency oscillations were significantly increased after acupuncture Zulinqi(GB41)in migraine patients without aura were the right central anterior gyrus,central posterior gyrus and other brain areas,and the significantly weakened brain areas were such as the left cuneiform and precuneus.Conclusion:Acupuncture Zulinqi(GB4

关 键 词：针刺 足临泣 无先兆偏头痛 低频振荡振幅 脑功能 静息态功能磁共振成像 机制 神经影像 

分 类 号：R245[医药卫生—针灸推拿学]