IL-33和IL1RL1基因单核苷酸多态性与特应性皮炎相关性研究  

Correlation between single nucleotide polymorphisms of IL-33/IL1RL1 genes and atopic dermatitis

作　　者：杨艳[1] 陈荃[1] 刘玉梅[1] 周欣[1] 田歆[1] 高爱莉[1] 熊斯颖[1] 陈晓吟[1] 李薇[1] 朱慧兰[1] YANG Yan;CHEN Quan;LIU Yumei;ZHOU Xin;TIAN Xin;GAO Aili;XIONG Siying;CHEN Xiaoyin;LI Wei;ZHU Huilan(Guangzhou Institute of Dermatology,Guangzhou 510095,China)

机构地区：[1]广州市皮肤病防治所,广东广州510095

出　　处：《中国麻风皮肤病杂志》2020年第11期649-652,共4页China Journal of Leprosy and Skin Diseases

基　　金：广东省医学科研基金资助课题(编号:A2018427);广州市医学卫生科技一般卫生项目引导项目(编号:20171A011283);广州市科技计划项目(编号:201904010082)。

摘　　要：目的:分析IL-33和IL1RL1基因单核苷酸多态性(SNPs)与特应性皮炎(AD)的相关性。方法:PCR-SSP方法检测89例AD患者和138名正常对照组受试者IL-33和IL1RL1编码基因的等位基因和基因型频率。结果:AD患者的IL-33 rs1800925 C等位基因的频率高于对照组,而T等位基因和rs764706552等位基因G低于对照组(均P<0.001)。IL-33 rs1800925基因型CC和rs764706552基因型CG与AD显著正相关(均P<0.001)。两组患者的IL1RL1基因的等位基因和基因型频率无明显差异(均P>0.05)。结论:IL-33基因可能与AD的发病相关。Objective:To analyze the association between the loci polymorphisms of IL-33,IL1RL1 gene and atopic dermatitis(AD).Methods:The allele and genotype frequencies of IL-33 and IL1RL1 encoding genes in 89 AD patients and 138 normal controls were detected by PCR-SSP.Results:The allele frequency of IL-33 gene rs1800925 C in the AD patients was higher than that in the controls.The allele frequencies of IL-33 gene rs1800925 T and rs764706552 G in the AD patients were lower than those in the controls(P s<0.001).The CC and CG genotypes frequencies of IL-33 rs1800925 and rs764706552 were significantly positively correlated with AD(P s<0.001).There was no significant difference in the frequencies of alleles and genotypes of IL1RL1 gene between the two groups(P s>0.05).Conclusion:rs1800925 and rs764706552 SNPs of IL-33 gene may be associated with the development of AD.

关 键 词：特应性皮炎 IL-33基因 单核苷酸多态性 

分 类 号：R758.2[医药卫生—皮肤病学与性病学]