冠心病患者循环内皮祖细胞与相关危险因素及冠状动脉病变的关系  

The relationship between EPCs of coronary artery disease patients,related risk factors and coronary lesion

作　　者：李顺东 钟丽颖 杨胜男 孙叶海 王聪 谢秀梅[2] Li Shundong;Zhong Liying;Yan Shengnan;Sun Yehai;Wang Cong;Xie Xiumei(Department of the Geriatrics,The Third hopital of Changsha,Changsha,Hunan,410000,China;Depatment of Internal Medicine-Cardiovascular,Xiangya Hospital,Changsha,Hunan,410000,China)

机构地区：[1]长沙市三医院老年病科,湖南长沙410000 [2]湘雅医院老年心内科,湖南长沙410000

出　　处：《当代医学》2020年第31期74-77,共4页Contemporary Medicine

基　　金：长沙市科技局基金(Kq1701012)。

摘　　要：目的研究冠心病患者循环内皮祖细胞与相关危险因素及冠状动脉病变的关系。方法选取2015年7月至2018年7月在本院进行冠状动脉造影检查者80例作为研究对象,其中造影检查异常者50例作为观察组,造影检查结果正常者30例作为对照组。比较两组患者的危险因素、内皮祖细胞的活性、分析循环内皮祖细胞与相关危险因素及冠状动脉病变的关系。结果患者的EPC水平与高脂血症、高血压和吸烟的相关性较强(P<0.05),与其他因素相关性较弱。对照组EPCs细胞克隆数为(35.4±7.8)个,单支血管病变者细胞克隆数为(14.9±4.1)个,双支血管病变者细胞克隆数为(11.8±5.2)个,三支及以上者细胞克隆数为(7.7±4.8)个,4组患者的EPCs细胞克隆数差异有统计学意义(P<0.05)。患者1~4 d的EPCs增殖能力差异无统计学意义,5~7 d的EPCs增殖能力差异有统计学意义(P<0.05)。结论冠心病患者循环内皮祖细胞与相关危险因素及冠状动脉病变的关系较为密切,相关危险因素抑制内皮祖细胞功能,而内皮祖细胞功能与冠状动脉病变相关。Objective To study whether the circulating endothelial progenitors cells of coronary artery disease patients might be associated with related risk factors and coronary lesion.Methods 80 patients who had underwent coronary angiography in our hospital from July 2015 to July 2018 were selected as study subjects.50 patients with abnormal results were choosen as the observation group,and the other 30 patients with normal results were choosen as the control group.Compare the risk factors and the activity of endothelial progenitor cells between the two groups,analyze the relationship between circulating endothelial progenitors cells,related risk factors and coronary lesion.Results The correlation of patients'level and hyperlipidaemia,high blood pressure and smoking were strong,but weak with other factors.The number of clone EPCs was(11.8±5.2)in control group,(14.9±4.1)in single-vessel disease patients,and(7.7±4.8)in triple-vessel disease patients.There was significant difference in the number of clone EPCs among the 4 groups(P<0.05).There was no significant difference in proliferative ability of EPCs within 1-4 d,but there was significant difference within 5-7 d(P<0.05).Conclusion The circulating endothelial progenitors cells of coronary artery disease patients have a close relationship with related risk factors and coronary lesion that the related risk factors can inhibit the function of EPCs,and EPCs are related to coronary lesion.

关 键 词：冠心病 内皮祖细胞 危险因素 冠状动脉病变 

分 类 号：R541.4[医药卫生—心血管疾病]