持续性静脉—静脉血液滤过治疗急性有机磷农药中毒伴呼吸衰竭的疗效观察  

Effect observation of continuous veno-venous hemofiltration in the treatment of acute organophosphorus pesticide poisoning with respiratory failure

作　　者：夏引芳 Xia Yinfang(Department of Emergency,Yingtan People's Hospital,Yingtan,Jiangxi,333000,China)

机构地区：[1]鹰潭市人民医院急诊科,江西鹰潭333000

出　　处：《当代医学》2020年第31期104-106,共3页Contemporary Medicine

摘　　要：目的探讨持续性静脉-静脉血液滤过治疗法对急性有机磷农药中毒伴呼吸衰竭患者的临床疗效。方法选取本院2016年12月至2018年10月收治的急性有机磷农药中毒伴呼吸衰竭患者76例作为研究对象,根据随机数表法分为两组,各38例。对照组患者予以常规治疗,观察组患者在对照组基础上接受持续性静脉-静脉血液滤过治疗,观察并分析两组临床治疗疗效、临床相关指标及炎症因子。结果治疗后,观察组总有效率为97.37%,明显高于对照组的78.95%,差异有统计学意义(P<0.05)。两组机械治疗通气时间比较差异无统计学意义;观察组意识恢复时间短于对照组,差异有统计学意义(P<0.05)。治疗后,两组TNF-ɑ、IL-6水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05)。结论持续性静脉-静脉血液滤过治疗能够有效地缩短急性有机磷农药中毒伴呼吸衰竭患者的意识恢复时间,降低患者炎症因子水平,提高患者临床疗效,值得应用与推广。Objective To investigate the clinical effect of continuous venous venous hemofiltration therapy in patients with acute organophosphorus pesticide poisoning with respiratory failure.Methods 76 patients with acute organophosphorus pesticide poisoning and respiratory failure treated in our hospital from December 2016 to October 2018 were taken as study subjects,and they were divided into two groups by random number table method,with 38 cases in each group.The control group were treated by routine treatment.On the basis of the control group,the observation group received continuous intravenous blood filtration treatment.The clinical therapeutic efficacy,clinical relevant indicators and inflammatory factors were observed and analyzed between the two groups of patients.Results After treatment,The total effective rate in the observation group was 97.37%,which was significantly higher than 78.95%in the control group,and the difference was statistically significant(P<0.05).There was significant difference in mechanical treatment ventilation time between the two groups;and the consciousness recovery time of the observation group was shorter than that of the control group,and the difference was statistically significant(P<0.05).The levels of TNF-ɑand IL-6 in the two groups were lower than before treatment,the observation group after treatment was lower than the control group,and the difference was statistically significant(P<0.05).Conclusion Continuous veno-venous hemofiltration therapy can effectively shorten the recovery time of consciousness of patients with acute organophosphorus pesticide poisoning and respiratory failure,reduce the level of inflammatory factors,and greatly improve the clinical therapeutic effect of patients.It is worthy of application and promotion.

关 键 词：急性有机磷农药中毒 呼吸衰竭 持续性静脉-静脉血液滤过 

分 类 号：R595.4[医药卫生—内科学] R563.8[医药卫生—临床医学]