面向生物控制的鲤鱼脑组织及脑电极三维重建  

Three-dimensional reconstruction of carp brain tissue and brain electrodes for biological control

作　　者：彭勇[1,2,3] 王爱迪 王婷婷 李京龙 王占秋[4] 赵洋[1] 王子霖 赵政 PENG Yong;WANG Aidi;WANG Tingting;LI Jinglong;WANG Zhanqiu;ZHAO Yang;WANG Zilin;ZHAO Zheng(Department of Biomedical Engineering,College of Electrical Engineering,Yanshan University,Qinhuangdao,Hebei 066004,P.R.China;Key Laboratory of National Defense of Mechanical Structure And Material Science Under Extreme Conditions,Yanshan University,Qinhuangdao,Hebei 066004,P.R.China;Institute of Marine Science And Engineering,Yanshan University,Qinhuangdao,Hebei 066004,P.R.China;Department of Magnetic Resonance,The First Hospital of Qinhuangdao Town,Qinhuangdao,Hebei 066004,P.R.China)

机构地区：[1]燕山大学电气工程学院生物医学工程系,河北秦皇岛066004 [2]燕山大学极端条件下机械结构和材料科学国防重点学科实验室,河北秦皇岛066004 [3]燕山大学海洋科学与工程研究院,河北秦皇岛066004 [4]秦皇岛市第一医院磁共振科,河北秦皇岛066004

出　　处：《生物医学工程学杂志》2020年第5期885-891,共7页Journal of Biomedical Engineering

基　　金：国家自然科学基金资助项目(61573305);河北省自然科学基金资助项目(F2019203511);国家高技术研究发展计划项目(863计划)。

摘　　要：为了给鲤鱼机器人脑电极准确植入进行定位导航,本研究拟建立脑结构及脑电极三维立体模型。借助脑立体定位仪将钨电极植入鲤鱼小脑,通过离水电刺激实验和水下控制实验发现脑运动区并获取其三维坐标值,应用3.0 T磁共振成像仪对颅脑及电极成像,应用3D-DOCTOR和Mimics软件进行三维重建。结果显示,所发现的脑运动区及坐标值是准确的,构建的脑组织及脑电极三维重建图再现了脑立体结构,可观察到脑电极与脑组织、脑组织与颅骨表面的相对空间位置关系;通过构建的脑组织三维重建综合显示图,可观察到三维重建的脑组织在磁共振图像中的解剖位置,以及脑组织与颅骨表面的相对空间位置关系。本研究所构建的三维重建模型可为脑电极植入提供定位导航工具。In order to accurately implant the brain electrodes of carp robot for positioning and navigation,the three-dimensional model of brain structure and brain electrodes is to be proposed in the study.In this study,the tungsten electrodes were implanted into the cerebellum of a carp with the aid of brain stereotaxic instrument.The brain motor areas were found and their three-dimensional coordinate values were obtained by the aquatic electricity stimulation experiments and the underwater control experiments.The carp brain and the brain electrodes were imaged by 3.0 T magnetic resonance imaging instrument,and the three-dimensional reconstruction of carp brain and brain electrodes was carried out by the 3D-DOCTOR software and the Mimics software.The results showed that the brain motor areas and their coordinate values were accurate.The relative spatial position relationships between brain electrodes and brain tissue,brain tissue and skull surface could be observed by the three-dimensional reconstruction map of brain tissue and brain electrodes which reconstructed the three-dimensional structure of brain.The anatomical position of the three-dimensional reconstructed brain tissue in magnetic resonance image and the relationship between brain tissue and skull surface could be observed through the three-dimensional reconstruction comprehensive display map of brain tissue.The threedimensional reconstruction model in this study can provide a navigation tool for brain electrodes implantation.

关 键 词：鲤鱼机器人 脑运动区 脑电极 磁共振成像 三维重建 

分 类 号：TP242[自动化与计算机技术—检测技术与自动化装置] TP391.41[自动化与计算机技术—控制科学与工程] R318[医药卫生—生物医学工程]