连续血液灌流联合持续静脉-静脉血液滤过在救治急性百草枯中毒中的应用  

Application of continuous hemoperfusion and continuous veno-venous hemofiltration in acute paraquat poisoning

作　　者：黄舒伟 陈群燕 刘炯 姚为学[1] HUANG Shu-wei;CHEN Qun-yan;LIU Jiong;YAO Wei-xue(Department of Emergency Center,Zhanjiang Central People's Hospital,Zhanjiang 524045,China)

机构地区：[1]广东省湛江中心人民医院急救中心,广东湛江524045

出　　处：《广东医科大学学报》2020年第5期609-612,共4页Journal of Guangdong Medical University

基　　金：湛江市科技计划项目(No.2018B01023)。

摘　　要：目的观察连续血液灌流(HP)联合持续静脉-静脉血液滤过(CVVH)在救治急性百草枯中毒(APP)中的应用效果。方法 90例APP患者分别采用连续HP治疗(对照组)或连续HP联合CVVH治疗(观察组),比较两组疗效、器官功能指标(Ⅲ型前胶原肽、丙氨酸氨基转移酶、肌酸激酶同工酶、血肌酐SCr)和炎症因子(C-反应蛋白、肿瘤坏死因子-α、白介素-10)变化。结果治疗7 d后,观察组疗效明显优于对照组(P<0.05),而器官功能指标和炎症因子水平均显著低于对照组(P<0.01)。结论连续HP联合CVVH治疗APP可提高疗效,减轻各器官损伤,降低炎症反应程度。Objective To observe the clinical efficacy of continuous hemoperfusion(CHP)and continuous veno-venous hemofiltration(CVVH)in acute paraquat poisoning(APP).Methods Ninety patients with APP were treated with CHP(control group)or CHP and CVVH(observation group).Clinical efficacy,organ function indicators(type III procollagen peptide,alanine aminotransferase,creatine kinase isoenzyme and serum creatinine),and inflammatory factors(C-reactive protein,tumor necrosis factor-α,and interleukin-10).Results After 7-day treatment,clinical efficacy was higher(P<0.05),while organ function indexes and levels of inflammatory factors were lower(P<0.01)in observation group compared with control group.Conclusion Combined CHP and CVVH can improve clinical efficacy,organ damage and inflammatory response in patients with APP.

关 键 词：百草枯中毒 血液灌流 持续静脉-静脉血液滤过 

分 类 号：R595.4[医药卫生—内科学]