载槲皮素纳米粒对人乳腺癌MCF-7细胞的增殖抑制作用研究  

Synthesis of Quercetin Loaded Nanoparticles and Evaluation of Their Cytotoxic Effects of Human Breast Cancer MCF-7 Cells

作　　者：侍慧慧 李飞飞 Shi Huihui;Li Feifei(School of Pharmacy Kang Da College of Nan Jing Medical University,Lianyungang 222000,China)

机构地区：[1]南京医科大学康达学院药学部,江苏连云港222000

出　　处：《广东化工》2020年第20期242-243,共2页Guangdong Chemical Industry

基　　金：南京医科大学2018年度科技发展基金(NMUB2018262);南京医科大学2019年度科技发展基金(NMUB2019273)。

摘　　要：目的:研究载槲皮素纳米粒对人乳腺癌MCF-7细胞增值抑制作用。方法:选择人乳腺癌MCF-7细胞,采用噻唑蓝比色法(MTT法)检测其细胞毒作用。结果:细胞毒实验中,相对于游离药物组,载槲皮素纳米粒(NP-Q)组表现出对MCF-7细胞有更强的杀伤作用。结论:本研究所制备的载槲皮素纳米粒有较强的杀伤人乳腺癌MCF-7细胞作用。Objective To study the cytotoxic effects of drug-carrying polymers nanoparticles.Methods MTT assay was used to detect the cytotoxic effect of human breast cancer MCF-7 cells.Results In the cytotoxic experiment,NP-Q nanoparticles showed a strong killing effect on MCF-7 cells.Conclusion In this study,NP-Q nanoparticles were used for the treatment of human breast cancer,it had strong cytotoxic effect on MCF-7 cells.

关 键 词：槲皮素 噻唑蓝比色法 MCF-7细胞 

分 类 号：TQ[化学工程]