喘息婴儿血清25-羟维生素D3水平测定及其临床意义  

Clinical Significance of Serum 25-hydroxy Vitamin D3 Levels in Asthmatic Infants

作　　者：王洪波[1] 宝瑞 王燕玲[1] 杨秀芹[1] 贺瑞荣[1] 蔡娟[1] WANG Hongbo;BAO Rui;WANG Yanling;YANG Xiuqin;HE Ruirong;CAI Juan(The First People's Hospital of Shizuishan,Shizuishan 753200,China)

机构地区：[1]石嘴山市第一人民医院,石嘴山753200

出　　处：《宁夏医科大学学报》2020年第10期1021-1024,共4页Journal of Ningxia Medical University

摘　　要：目的探讨婴儿血清25-(OH)D3水平与喘息的关系及其临床意义。方法选择2013年1月至2016年6月我院收治的113例伴有不同喘息症状的急性发作期患儿为喘息组,根据患儿有无喘息发作史,分为首次喘息组(59例)和反复喘息组(54例),选择同期我院收治的115例急性下呼吸道感染但不伴有喘息患儿为非喘息组,选择同期在我院儿童保健门诊进行常规体检的健康婴幼儿120例为对照组。采用LC-MS/MS测定血清25-(OH)D3水平,采用直接免疫荧光法检测7种常见呼吸道病毒抗原,采用荧光酶联免疫法检测过敏原。结果(1)反复喘息组血清25-(OH)D3水平低于首次喘息组、非喘息组及对照组,首次喘息组血清25-(OH)D3水平低于非喘息组、对照组,非喘息组血清25-(OH)D3水平低于对照组(P均<0.05);血清25-(OH)D3<75 nmol·L^-1患儿中,喘息患儿比例高于非喘息患儿,反复喘息患儿比例高于首次喘息患儿(P均<0.05);(2)反复喘息组病毒检出阳性率高于首次喘息组、非喘息组(P均<0.05);首次喘息组与非喘息组病毒检出阳性率差异无统计学意义(P>0.05);三组过敏原检出率差异无统计学意义(P>0.05);(3)血清25-(OH)D3水平<75 nmol·L^-1患儿中病毒阳性检出率高于25-(OH)D3水平≥75 nmol·L^-1患儿(P<0.05),而两组过敏原阳性检出率差异无统计学意义(P>0.05)。结论病毒感染是婴儿喘息发生的主要因素,维生素D缺乏或不足可能参与婴儿喘息的发生及发展,可能增加反复喘息发生的风险。Objective To explore the correlations between the serum 25-hydroxy vitamin D3 levels in asthmatic infants and its clinical significance.Methods A total of 113 cases of infants with acute exacerbation of wheezing admitted to our hospital from January 2013 to June 2016 were collected as asthmatic group,and divided into the first time wheezing group and recurrent wheezing group(more than 2 episodes of wheezing)according to the history of children without wheezing.115 cases of infants with acute lower respiratory tract infections but not associated with wheezing in our hospital during the same period were collected as non-asthmatic group,and 120 cases of healthy infants with routine physical examination in the outpatient department of our hospital as control group.The serum 25-hydroxy vitamin D3 levels in three groups were detected by LC-MS/MS,7 kinds of common respiratory virus antigens were examined by direct immunofluorescence assay and serum allergen was checked by fluorescence enzyme immunoassay.Results(1)The serum level of 25-hydroxy vitamin D3 in recurrent wheezing group was lower than that of the first time wheezing group,non-asthmatic group and control group,serum level of 25-hydroxy vitamin D3 in the first time wheezing group was lower than non-asthmatic group and control group,serum level of 25-hydroxy vitamin D3 in non-asthmatic group was lower than control group(P all<0.05).In infants with serum level of 25-hydroxy vitamin D3<75 nmol·L^-1,the proportion of children with wheezing was higher than non-wheezing children and the proportion of infants with gasping repeated was higher than first wheezy children(P all<0.05).(2)The positive detection rate of virus in recurrent wheezing group was higher than the first time wheezing group and non-asthmatic group(P all<0.05).There was no significant difference in the positive detection rate of virus between the first time wheezing group and non-asthmatic group(P>0.05).There was no significant difference in the detection rate of serum allergen among the three groups

关 键 词：喘息婴儿 反复喘息 血清25-羟维生素D3水平 

分 类 号：R725.6[医药卫生—儿科]