苔黑酚葡萄糖苷的合成  

Synthesis of Orcinol Glucoside

作　　者：王波[1] 钟婷 何贝桥 胡亚丹 张园园[2] WANG Bo;ZHONG Ting;HE Beiqiao;HU Yadan;ZHANG Yuanyuan(People’s Hospital of Ningxia Hui Autonomous Region,Yinchuan 750001,China;School of Chinese Materia Medica,Beijing University of Chinese Medicine,Beijing 100049,China)

机构地区：[1]宁夏回族自治区人民医院,银川750001 [2]北京中医药大学中药学院,北京100049

出　　处：《宁夏医科大学学报》2020年第10期1073-1076,共4页Journal of Ningxia Medical University

基　　金：2017年宁夏卫生健康委重点项目(2017-NW-032)。

摘　　要：目的利用化学方法对中药仙茅的活性成分苔黑酚葡萄糖苷进行合成。方法以5-甲基-1,3-苯二酚为原料,经苄基化保护、相转移催化法成苷、水解、还原,制得苔黑酚葡萄糖苷。结果所制得产物苔黑酚-β-D-葡萄糖苷结构经1H-NMR和13C-NMR确证,化合物的纯度为99.6%,总收率44.6%。结论方法具有收率高、工艺简单、稳定可行的特点,可为苔黑酚葡萄糖苷的进一步研究开发奠定基础。Objective To prepare orcinol glucoside,the active component from Curculigo orchioides Gaertn by using chemical synthesis method.Methods 5-Methyl-1,3-benzenediol was used as raw material.Orcinol glucoside was prepared by glycoside protection,phase transfer catalysis method to form glycosides,hydrolysis,and deprotection.Results The purity of the target compound was 99.6%,and the total yield was 44.6%.The structure was confirmed by 1H-NMR and 13C-NMR.Conclusion The method has the characteristics of high yield,simple process,stable and feasible,which can lay the foundation for further research and development of orcinol glucoside.

关 键 词：仙茅 苔黑酚葡萄糖苷 合成 相转移催化法 

分 类 号：R284[医药卫生—中药学]