血脂清对痰瘀互结型H型高血压颈动脉内膜中层厚度及血压变异性的影响  

Effect of Xuezhiqing on Carotid Intima-media Thickness and Blood Pressure Variability of H-type Hypertension with Phlegm and Blood Stasis

作　　者：阮秋红 叶靖[1] 郑燕慧[1] 吴志阳[1] 陈晓军 王雳 RUAN Qiuhong;YE Jing;ZHENG Yanhui;WU Zhiyang;CHEN Xiaojun;WANG Li(Quanzhou Hospital of Traditional Chinese Medicine,Quanzhou 362000,China)

机构地区：[1]泉州市中医院,福建泉州362000

出　　处：《中外医学研究》2020年第28期16-19,共4页CHINESE AND FOREIGN MEDICAL RESEARCH

基　　金：泉州市高层次人才创新创业项目(2017Z040)。

摘　　要：目的:观察血脂清对痰瘀互结型H型高血压颈动脉内膜中层厚度(CIMT)及血压变异性的影响。方法:采用随机数字表法将76例患者分为试验组和对照组,各38例。对照组采用马来酸依那普利片+叶酸片治疗,试验组采用马来酸依那普利片+血脂清颗粒治疗。比较两组治疗前后同型半胱氨酸(Hcy)、CIMT及血压变异性。结果:治疗后,两组血清Hcy均较治疗前降低,且试验组低于对照组,差异有统计学意义(P<0.05)。治疗后,两组24 h SBP、24 h DBP均较治疗前明显降低,且试验组均低于对照组,差异有统计学意义(P<0.05)。治疗后,两组24 h SCV、24 h DCV均较治疗前降低,且试验组均低于对照组,差异有统计学意义(P<0.05)。两组治疗后24 h SSD、24 h DSD均较治疗前降低,且试验组均低于对照组,差异有统计学意义(P<0.05)。治疗后,两组CIMT均较治疗前降低,且试验组低于对照组,差异有统计学意义(P<0.05)。结论:血脂清对痰瘀互结型H型高血压患者具有一定的临床疗效,能够降低患者的CIMT及24 h动态血压变异性,同时改善患者的症状,值得进一步研究及推广。Objective:To observe the effect of Xuezhiqing on carotid intima-media thickness (CIMT) and blood pressure variability of H-type hypertension with phlegm and blood stasis.Method:A total of 76 patients were divided into the experimental group and the control group by random number table method,with 38 cases in each group.The control group was treated with Enalapril Maleate Tablet+Folic Acid Tablet,while the experimental group was treated with Enalapril Maleate Tablet+Xuezhiqing Granules.The homocysteine (Hcy),CIMT and blood pressure variability were compared between the two groups before and after treatment.Result:After treatment,the serum Hcy of the two groups were lower than those before treatment,and the experimental group was lower than the control group,the differences were statistically significant (P<0.05).After treatment,24 h SBP and 24 h DBP of the two groups were significantly lower than those before treatment,and the experimental group was lower than the control group,the differences were statistically significant (P<0.05).After treatment,the 24 h SCV and 24 h DCV of the two groups were lower than those before treatment,and the experimental group was lower than the control group,the differences were statistically significant (P<0.05).After treatment,24 h SSD and 24 h DSD of the two groups were lower than those before treatment,and the experimental group was lower than the control group,the differences were statistically significant (P<0.05).After treatment,CIMT of the two groups were lower than those before treatment,and the experimental group was lower than the control group,the differences were statistically significant (P<0.05).Conclusion:Xuezhiqing has a certain clinical effect on H-type hypertension patients with phlegm and blood stasis.It can reduce CIMT and 24 h ambulatory blood pressure variability,and improve the symptoms of patients,which is worthy of further research and promotion.

关 键 词：血脂清 H型高血压 痰瘀互结 血压变异性 颈动脉内膜中层厚度 

分 类 号：R544.1[医药卫生—心血管疾病]