甲巯咪唑治疗甲状腺功能亢进症的效果及对血清TRAb、Tg的影响  

Effects of Methimazole in the Treatment of Hyperthyroidism and Its Effect on Serum TRAb and Tg

作　　者：赖胜华 周舸 丘文达 LAI Shenghua;ZHOU Ge;QIU Wenda(Dongguan Shuixiang Central Hospital,Dongguan 523142,China;不详)

机构地区：[1]广东省东莞市水乡中心医院,广东东莞523142

出　　处：《中国医学创新》2020年第29期23-26,共4页Medical Innovation of China

基　　金：东莞市社会科技发展(一般)项目(201950715019378)。

摘　　要：目的:研究采用甲巯咪唑治疗甲状腺功能亢进的效果及对血清TRab、Tg的影响。方法:采用分层抽样法选取2019年1-8月在本院治疗的108例甲状腺功能亢进患者作为研究对象,按入院单双号分为观察组和对照组,各54例。两组患者在入院后均接受常规支持治疗,在此基础上,对照组患者接受丙硫氧嘧啶治疗,观察组患者接受甲巯嘧啶治疗。比较两组患者治疗前后的甲状腺球蛋白(Tg)、促甲状腺激素受体抗体(TRAb)、游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)、促甲状腺激素(TSH)、过氧化物酶抗体(TPOAb),甲状腺球蛋白抗体(TgAb)、半胱氨酸蛋白酶抑制剂C(Cys C)水平;比较两组的治疗效果和不良反应发生情况。结果:治疗后,两组患者的FT3、FT4均显著低于治疗前,TSH显著高于治疗前(P<0.05);治疗后,观察组的FT3、FT4均显著低于对照组,TSH显著高于对照组(P<0.05)。治疗后,两组患者的TPOAb、TgAb、TRAb均显著低于治疗前,且观察组均显著低于对照组(P<0.05)。治疗后,两组患者的血清Cys C、Tg水平均显著低于治疗前(P<0.05);治疗后,观察组的Cys C、Tg水平均显著低于对照组(P<0.05)。治疗后,观察组总有效率显著高于对照组(P<0.05)。观察组不良反应发生率低于对照组,差异有统计学意义(P<0.05)。结论:临床上采用甲巯嘧啶治疗甲状腺功能亢进症患者,效果显著,可改善甲状腺功能各项指标,不良反应较少,是一种安全可靠治疗方案,具有较高的临床推广价值。Objective:To investigate the effect of Methimazole in the treatment of hyperthyroidism and its effect on serum TRAb and Tg.Method:A total of 108 patients with hyperthyroidism treated in our hospital from January to August 2019 were selected as subjects by stratified sampling,who were divided into observation group and control group by admission of odd-even numeral method,54 cases in each.After admission,patients in both groups received routine supportive treatment,including infection prevention,fasting from spicy food,and reasonable supplementation of Calcium and Vitamins.Patients in the control group were treated with Prop-ylthiouracil,patients in the observation group were treated with Methimazole.The levels of Tg,TRAb,FT3,FT4,TSH,TPOAb,TgAb,Cys Cof the two groups before and after treatment were compared;the treatment effect and the occurrence of adverse reactions were compared between the two groups.Result:FT3 and FT4 in the two groups were significantly lower than those before treatment,and TSH was significantly higher than those before treatment(P<0.05);after treatment,FT3 and FT4 in the observation group were significantly lower than those in the control group,and TSH was significantly higher than that in the control group.TPOAb,TgAb and TRAb of the two groups were significantly lower than those before treatment(P<0.05),TPOAb,TgAb and TRAb of the observation group were significantly lower than those of the control group after treatment(P<0.05).After treatment,the serum levels of Cys C and Tg in the two groups were significantly lower than those before treatment(P<0.05),the levels of Cys C and Tg in the observation group were significantly lower than those in the control group(P<0.05).The total effective rate in the observation group was significantly higher than that in the control group(P<0.05).The total incidence of adverse reactions in the observation group was significantly lower than that in the control group(P<0.05).Conclusion:In clinical practice,methtothiazine is used to treat patients with hyperthy

关 键 词：甲状腺功能亢进 甲巯咪唑 丙硫氧嘧啶 

分 类 号：R581.1[医药卫生—内分泌]