PCI术中冠脉内注射替罗非班对老年ACS患者凝血功能及TIMI血流分级的影响  

Effects of Intracoronary Injection of Tirofiban on Coagulation Function and TIMI Blood Grading in Elderly ACS Patients during PCI

作　　者：周敏 ZHOU Min(Pingxiang NO.2 People’s Hospital,Pingxiang 337000,China)

机构地区：[1]江西省萍乡市第二人民医院,江西萍乡337000

出　　处：《中国医学创新》2020年第26期35-38,共4页Medical Innovation of China

摘　　要：目的:探讨PCI术中冠脉内注射替罗非班对老年急性冠脉综合征(acute coronary syndrome,ACS)患者凝血功能及TIMI血流分级的影响。方法:选取2017年6月-2019年6月本院确诊为ACS的老年患者76例,根据治疗方式不同分为对照组和研究组,各38例。两组患者入院时均给予常规治疗,对照组行冠脉造影,根据造影结果行常规PCI术,研究组除行常规PCI术治疗外,术中加入替罗非班的使用。比较两组治疗后凝血功能情况、TIMI血流分级及不良反应发生情况。结果:研究组治疗后纤维蛋白原低于治疗前,凝血酶时间、活化部分凝血酶时间、凝血酶原时间均长于治疗前,差异均有统计学意义(P<0.05);对照组治疗后纤维蛋白原高于治疗前,凝血酶时间、活化部分凝血活酶时间、凝血酶原时间均短于治疗前,差异均有统计学意义(P<0.05);治疗后,研究组纤维蛋白原低于对照组,凝血酶时间、活化部分凝血酶时间、凝血酶原时间均长于对照组,TIMI血流分级优于对照组,差异均有统计学意义(P<0.05)。研究组不良反应发生率低于对照组,差异有统计学意义(P<0.05)。结论:PCI术中冠脉内注射替罗非班治疗老年ACS患者,可有效改善凝血功能和冠脉血流情况,减少术后不良反应,值得临床推广应用。Objective:To study the effects of intravenous Tirofiban on coagulation function and TIMI blood levels in elderly patients with acute coronary syndrome (ACS) during PCI.Method:A total of 76 elderly patients diagnosed with ACS in our hospital from June 2017 to June 2019 were selected,they were divided into control group and study group,38 cases in each group,according to different treatment methods.Patients in the two groups were given conventional treatment on admission,coronary angiography was performed in the control group,and conventional PCI was performed according to the contrast results,besides conventional PCI,tirofiban was added to the study group during the operation.The coagulation function,TIMI blood grading and adverse reactions of the two groups were compared after treatment.Result:The fibrinogen after treatment in the study group was lower than that before treatment,the thrombin time,activated partial thrombin time,and prothrombin time were all longer than those before treatment,the differences were statistically significant (P<0.05).The fibrinogen after treatment in the control group was higher than that before treatment,thrombin time and activated fraction Thromboplastin time and prothrombin time were shorter than those before treatment,the differences were statistically significant (P<0.05).The fibrinogen in the study group was lower than that of the control group,thrombin time,activated partial thrombin time and prothrombin time in the study group were longer than those in the control group,TIMI blood flow classification in the study group was better than that in the control group,the differences were statistically significant (P<0.05).The adverse reaction rate in the study group was lower than that in the control group,the difference was statistically significant (P<0.05).Conclusion:Intracoronary injection of Tirofiban during PCI for the treatment of elderly ACS patients can effectively improve the coagulation function and coronary blood flow,reduce postoperative adverse reactions,and is worthy

关 键 词：凝血功能 急性冠脉综合征 经皮冠状动脉介入术 替罗非班 心肌梗死 

分 类 号：R541.4[医药卫生—心血管疾病]