神经源性异位骨化发病机制的研究进展  

Research progress in pathogenesis of neurologic heterotopic ossification

作　　者：刘以俊[1] 寇玉辉[1] 张殿英[1,2] 姜保国[1] Liu Yijun;Kou Yuhui;Zhang Dianying;Jiang Baoguo(Department of Traumatic Orthopedics,Institute of Trauma and Nerve Regeneration,Peking University People's Hospital,Beijing 100044,China;Department of Orthopedics,Peking University Binhai Hospital,Tianjin 300450,China)

机构地区：[1]北京大学人民医院创伤骨科,创伤与神经再生研究所,100044 [2]北京大学滨海医院骨科,天津300450

出　　处：《中华创伤杂志》2020年第9期853-858,共6页Chinese Journal of Trauma

基　　金：教育部创新团队(IRT16R01);创伤救治与神经再生教育部重点实验室(北京大学)(BMU2019XY007-01)。

摘　　要：神经源性异位骨化(NHO)是在软组织中出现新生骨组织的现象,与中枢神经损伤相关,可引起肢体活动障碍、剧烈疼痛和皮肤溃疡等严重并发症,其发病机制尚不明确。近年针对NHO的发病机制有了更深入的研究,并据此提出了新的监测和治疗靶点。笔者从促进成骨诱导因素、成骨前体细胞、成骨微环境三个方面对NHO的发病机制进行综述,为临床诊疗提供依据。Neurologic heterotopic ossification(NHO)is a pathological phenomenon that involves the formation of ectopic bone in soft tissues,which is associated with central nervous system injury.NHO may cause severe complications such as disorder of limb's activity,severe pain,and skin ulcer.The pathogenesis of NHO is not clear.In the past decades,there's better understanding of NHO pathogenesis,and potential predictive and therapeutic targets were found.The authors overview the NHO pathogenesis based on osteogenic factors,osteogenic precursor cells and microenvironments,soas to provide references for clinical diagnosis and treatment.

关 键 词：骨化 异位性 骨形态发生蛋白质类 间充质干细胞 

分 类 号：R681[医药卫生—骨科学]