恩替卡韦抗病毒治疗乙型肝炎肝硬化失代偿期患者的临床疗效  

Clinical Effect of Entecavir Antiviral Treatment on Patients with Hepatitis B Liver Cirrhosis in Decompensated Stage

作　　者：王慧 WANG Hui(Hospital of Jinzhou People's Liberation Army,Jinzhou 121000,China)

机构地区：[1]锦州市解放军第968医院,辽宁锦州121000

出　　处：《中国医药指南》2020年第27期35-36,共2页Guide of China Medicine

摘　　要：目的探讨恩替卡韦抗病毒治疗乙型肝炎肝硬化失代偿期患者的临床疗效。方法选择我院2015年1月至2018年1月收治的100例乙型肝炎肝硬化失代偿期患者,随机分为拉米夫定治疗组与恩替卡韦联合拉米夫定治疗组,各50例。拉米夫定治疗组患者予以拉米夫定治疗,恩替卡韦联合拉米夫定治疗组患者予以拉米夫定联合恩替卡韦治疗。比较两组临床疗效;治疗前后肝功能指标(总胆红素、天冬氨酸转氨酶、丙氨酸转氨酶)、生活质量评分;乙型肝炎病毒的脱氧核糖核酸(HBV-DNA)转阴时间、平均住院时间;药物使用中不良反应发生率。结果恩替卡韦联合拉米夫定治疗组总有效率、总胆红素、天冬氨酸转氨酶、丙氨酸转氨酶、生活质量评分、HBV-DNA转阴时间、平均住院时间均优于拉米夫定治疗组,P<0.05。结论恩替卡韦联合拉米夫定的用药方案对于乙型肝炎肝硬化失代偿期患者,治疗的效果非常明显,有利于患者肝功能情况的改善,并促使患者生存质量提高,用药方案安全性高。Objective To explore the clinical efficacy of entecavir antiviral treatment for patients with hepatitis B liver cirrhosis in decompensated stage.Methods Selected 100 patients with decompensated hepatitis B liver cirrhosis admitted in our hospital from January 2015 to January 2018,and randomly divided them into the lamivudine treatment group and the entecavir combined with lamivudine treatment group,with 50 cases in each.Patients in the lamivudine treatment group were treated with lamivudine,and patients in the entecavir combined with lamivudine treatment group were treated with lamivudine and entecavir.Comparison of clinical efficacy between the two groups;liver function indicators(total bilirubin,aspartate aminotransferase,alanine aminotransferase),quality of life score before and after treatment;hepatitis B virus deoxyribonucleic acid(HBV-DNA)time to negative and average hospital stay time;the incidence of adverse reactions during drug use.Results The total effective rate,total bilirubin,aspartate aminotransferase,alanine aminotransferase,quality of life score,HBV-DNA negative time,and average length of hospital stay in the entecavir combined with lamivudine treatment group were better than those in the lamivudine treatment group,P<0.05.Conclusion The medication regimen of entecavir combined with lamivudine has a very obvious therapeutic effect for patients with decompensated hepatitis B cirrhosis,which is beneficial to the improvement of patients'liver function and improves the quality of life of patients.The medication regimen is highly safe.

关 键 词：乙型肝炎肝硬化失代偿期 恩替卡韦 拉米夫定 临床疗效 肝功能 生活质量 

分 类 号：R512.62[医药卫生—内科学] R575.2[医药卫生—临床医学]