N-芳氧乙酰基-N′-异烟酰胺基硫脲的合成与除草活性  

Synthesis and Herbicidal Activity of N-Aryloxyacetyl-N′-isonicotinamido Thiourea

作　　者：郑广进[1] 曾振芳[1] 张海全[1] ZHENG Guang-jin;ZENG Zhen-fang;ZHANG Hai-quan(Guangxi Colleges and Universities Key Laboratory Breeding Base of Chemistry of Guangxi Southwest Plant Resources,Guangxi Normal University for Nationalities,Chongzuo 532200,Guangxi,China)

机构地区：[1]广西民族师范学院,广西高校桂西南特色植物资源化学重点实验室培育基地,广西崇左532200

出　　处：《农药》2020年第10期715-718,共4页Agrochemicals

基　　金：广西民族师范学院校级科研项目(2016YB030);2013年度广西高校科学技术研究项目(2013YB271)。

摘　　要：[目的]寻求具有除草活性的酰基硫脲类先导化合物。[方法]以芳氧乙酸和异烟肼为原料,经卤化、取代和缩合反应合成了6个酰基硫脲类化合物,并进行除草活性测试。[结果]目标化合物结构经~1H NMR、IR和MS确证。除草活性测试结果表明:在200 mg/L质量浓度下,所有目标化合物均表现出一定的除草活性,其中化合物4c^4f对龙爪茅根和鬼针草根的抑制率分别达到80%和90%以上。[结论]化合物4c^4f具有较强的除草活性,可作为先导化合物进行进一步结构优化。[Aims]The study aims to search for new acylthiourea lead compounds possessing herbicide activities.[Methods]Six acylthiourea derivatives were synthesized from aryloxyacetic acid and isoniazid by reactions of halogenation,substitution and condensation,and the herbicidal activity of the target compounds was tested.[Results]The title compounds were characterized by^1H NMR,IR and MS.The results of herbicidal activity test showed that all the target compounds displayed some herbicidal activities at the concentration of 200 mg/L.Where in the inhibition rate of compounds 4c-4f against the root of Dactyloctenium aegyptiu and Bidens pilosa were up to 80 and 90%,respectively.[Conclusions]The compounds 4c-4f shows good herbicidal activity,they can be used as lead compounds for further structural optimization.

关 键 词：芳氧乙酸 酰基硫脲 合成 除草活性 

分 类 号：TQ460.3[化学工程—制药化工]