铁皮石斛花对孕鼠母体和仔鼠出生前毒性的研究  

Toxicity of Dendrobium officinale flowers to pregnant rats and offspring rats before birth

作　　者：傅剑云[1] 夏勇[1] 郑云燕[1] 蔡德雷[1] 何佳维 宋燕华[1] FU Jianyun;XIA Yong;ZHENG Yunyan;CAI Delei;HE Jiawei;SONG Yanhua(Zhejiang Provincial Center for Disease Control and Prevention.Hangzhou,Zhejiang 3 J0051.China)

机构地区：[1]浙江省疾病预防控制中心,浙江杭州310051

出　　处：《预防医学》2020年第10期1000-1003,共4页CHINA PREVENTIVE MEDICINE JOURNAL

摘　　要：目的研究铁皮石斛花对孕鼠母体和仔鼠出生前毒性,为评价铁皮石斛花安全性提供毒理学依据。方法设低、中、高3个剂量组和对照组,每组雌鼠20只,雄鼠10只。各剂量组喂饲受试物饲料,受试物的量分别为2.0、4.0、6.4 g/kgbw;对照组喂饲基础饲料。繁殖二代(F1、F2),F1a和F2a喂饲基础饲料,F1b和F2b喂饲含受试物饲料。测定并比较大鼠体重、总增重、受孕率、妊娠率、仔鼠出生体重和存活率。结果 4组P、F1b孕鼠第一次和第二次妊娠的体重、总增重、受孕率和妊娠率差异均无统计学意义(P>0.05)。各剂量组F1、F2仔鼠出生存活率和出生活仔率与对照组比较,差异均无统计学意义(P>0.05)。结论未发现铁皮石斛花对P、F1孕鼠母体和F1、F2仔鼠出生前有明显不良影响。Objective To learn the toxicity of Dendrobium officinale flowers to pregnant rats( P, F1) and offspring rats(F1, F2) before birth, so as to provide toxicological evidence for the safety assessment.MethodsThe rats were divided into four groups with 20 female rats and 10 male each. The rats in three dose groups were fed with Dendrobium officinale flowers at the dose of 2.0, 4.0, 6.4 g/kgbw. After two generation, the F1 a and F2 a rats were fed with basal diet;F1 b and F2 b rats were fed with Dendrobium officinale flowers. The body weights and total weight gains during the gestation,the conception rates, the pregnancy rates, the birth weights and survival rates of offspring rats were examined.Results There were no statistically significant differences in the body weights and total weight gains during the gestation, the conception rates, and the pregnancy rates in pregnant rats( P, F1) among the four groups( P>0.05). There were also no statistically significant differences in the survival rates and live birth rates in offspring rats(F1, F2) between the dose groups and the control group( P>0.05).Conclusion Dendrobium officinaleflowers did not show obviously adverse effects on pregnant rats(P, F1) and offspring rats(F1, F2) before birth.

关 键 词：铁皮石斛花 大鼠 母体毒性 出生前毒性 

分 类 号：R285[医药卫生—中药学]