早期帕金森病相关脑结构的定量磁化率成像  

Quantitative susceptibility mapping of early-stage Parkinson’s disease related brain structure

作　　者：庄晗 刘学玲 秦春丽 王辉 李郁欣 李文生 史勇红 ZHUANG Han;LIU Xue-ling;QIN Chun-li;WANG Hui;LI Yu-xin;LI Wen-sheng;SHI Yong-hong(Department of Anatomy,Histology and Embryology.,School of Basic Medical Sciences,Fudan University,Shanghai 200032,China;Digital Medical Research Center,School of Basic Medical Sciences,Fudan University,Shanghai 200032,China;Shanghai Key Laboratory of Medical Imaging Computing and Computer-Assisted Intervention,Shanghai 200032,China;Department of Radiology,Huashan Hospital,Fudan University,Shanghai 200040.China)

机构地区：[1]复旦大学基础医学院人体解剖学与组织学胚胎学系,上海200032 [2]复旦大学基础医学院数字医学研究中心,上海200032 [3]上海市医学图像处理与计算机辅助手术重点实验室,上海200032 [4]复旦大学附属华山医院影像科,上海200040

出　　处：《解剖学报》2020年第5期738-744,共7页Acta Anatomica Sinica

基　　金：国家重点研究开发项目(2017YFC0110701)。

摘　　要：目的应用3T磁共振T1加权成像和定量磁化率成像分析早期帕金森病(PD)患者深部灰质核团体积的变化,探究深部灰质核团磁化率值在帕金森病患者和健康对照者之间的差异,探讨磁化率值在早期PD诊断中的意义,以及定量磁化率成像对于黑质小体-1的显示情况。方法30例早期PD患者和27例年龄、性别、教育程度匹配的健康对照者,分割双侧尾状核、壳核、苍白球、黑质和红核,测量核团的体积和平均磁化率值,使用SPSS20.0软件对数据进行统计学分析,并对磁化率值进行逻辑回归。结果早期PD患者组和健康对照组上述核团标准化体积之间差异无显著性;早期PD患者组右侧苍白球、左侧黑质和右侧黑质的磁化率值显著高于健康对照组(P<0.05);上述核团磁化率值经逻辑回归变换后得到的受试者工作特征曲线下面积为0.93;在21例健康对照者和1例早期PD患者的定量磁化率图像上看到了黑质小体-1。结论定量磁化率图像在诊断早期PD中具有很高的应用价值;大部分健康对照者的黑质小体-1在定量磁化率图像上可以显示,但更精确的研究需要<1mm分辨率的定量磁化率图像。Objective Using 3T T1 weighted magnetic resonance imaging and quantitative susceptibility mapping to analyse the early-stage Parkinson’s disease(PD)patients’volume and susceptibility value changes of deep gray matter nuclei,and to explore the significance of susceptibility values in diagnosis of early-stage PD,as well as observability of nigrosome-1 in this study.Methods 3.0 T MRI scans were performed in 30 early-stage PD patients and 27 age-,sex-and education matched healthy controls.Bilateral caudate,putamen,globus pallidus,substantia nigra and red nucleus were segmented.Their volumes and susceptibility values were calculated.SPSS 20.0 software was used to analyze the differences between the two groups.We also performed a logistic regression using the susceptibility values.Results There was no difference in the standardized volume of the above nuclei between the early-stage PD patients and the healthy controls.The susceptibility values of the right globus pallidus,the left substantia nigra and the right substantia nigra(P<0.05)in the early-stage Parkinson’s disease group were significantly higher than those in the healthy controls.The area under the receiver operating characteristic curve obtained by logistic regression using susceptibility values was 0.93.Nigrosome-1 was seen in 21 healthy controls and 1 early-stage PD patient.Conclusion As a marker of early diagnosis of PD,the susceptibility value has high application value.Nigrosome-1 in most healthy controls can be displayed on quantitative susceptibility images,but more accurate studies of nigrosome-1 require quantitative susceptibility mapping at submillimeter resolution.

关 键 词：早期帕金森病 深部灰质核团 黑质小体-1 T1加权成像 定量磁化率成像 磁共振成像 人 

分 类 号：R322.81[医药卫生—人体解剖和组织胚胎学]