桑柏生发剂治疗脱发的临床观察  

Sangbai Shengfa liniment in the treatment of alopecia

作　　者：杨东清 蔡云[1] 吴承艳[1] 吴承玉[1] 周雯[1] 张蕾[1] YANG Dong-qing;CAI Yun;WU Cheng-yan;WU Cheng-yu;ZHOU Wen;ZHANG Lei(Nanjing University of Chinese Medicine,Nanjing,Jiangsu 210023,China)

机构地区：[1]南京中医药大学,江苏南京210023

出　　处：《中国临床研究》2020年第10期1400-1402,1406,共4页Chinese Journal of Clinical Research

基　　金：江苏省自然科学基金项目(BK20131418);江苏省社会科学基金重点项目(18LSA002).

摘　　要：目的观察桑柏生发剂对脱发患者的临床疗效。方法选择2015年1月至2016年3月门诊治疗的70例“郁热虫浊”型斑秃及“郁热虫浊”型脂溢性脱发患者中,实际完成研究的60例,随机分为观察组和对照组,各30例。观察组使用桑柏生发剂(获国家发明专利:LZ200810196315.2,由南京中医药大学制药厂精制),对照组使用2%米诺地尔酊外用治疗。观察比较两组用药6个月的综合疗效。结果治疗6个月后,观察组与对照组总有效率差异无统计学意义(86.67%vs80.00%,P>0.05)。经桑柏生发剂治疗患者,其淋巴细胞亚群CD3^+、CD4^+/CD8^+呈升高趋势,但差异无统计学意义(P=0.106,P=0.104),CD4^+、CD8^+、CD19^+和CD16^+/CD56^+与治疗前比无明显变化(P均>0.05);经米诺地尔酊治疗患者,除CD3^+高于治疗前(P=0.037)、CD4^+/CD8^+呈升高趋势(P=0.052)外,其他各项差异均无统计学意义(P均>0.05)。治疗后,观察组患者CD4^+高于对照组(P=0.010),其他各项两组间差异均无统计学意义(P均>0.05)。结论外用桑柏生发搽剂治疗“郁热虫浊”型脱发与外用米诺地尔酊疗效相近,两种外用药治疗脱发头皮局部炎症不会对全身的免疫指标产生显著影响,且无明显毒副作用。Objective To observe the clinical effect of Sangbai Shengfa liniment in the treatment of patients with alopecia.Methods Out of 70 patients with alopecia areata and seborrheic alopecia(stasis-heat and microbial turbidity type)from January 2015 to March 2016,60 cases were selected and randomly divided into observation group and control group(n=30,each).Sangbai Shengfa liniment(National Invention Patent:LZ200810196315.2,refined by the pharmaceutical factory of Nanjing University of traditional Chinese Medicine)was used in observation group,and 2%minoxidil tincture topical was used in control group.The comprehensive treatment effect was observed and compared between two groups after treatment of 6 months.Results There was no statistical difference in the total effective rate between two groups(86.67%vs 80.00%,P>0.05).In observation group,the levels of CD3^+,CD4^+/CD8^+showed an increasing trend,but there were no significant differences in them(P=0.106,P=0.104)and in the levels of CD4^+,CD8^+,CD19^+and CD16^+/CD56^+compared with those before treatment(all P>0.05).In control group,only CD3^+level was higher than that before treatment(P=0.037),and CD4^+/CD8^+showed an increasing trend(P=0.052).After treatment,the level of CD4^+in observation group was statistically higher than that in control group(P=0.010),and there were no significant differences in other items between two groups(all P>0.05).Conclusion In the treatment of alopecia areata and seborrheic alopecia(stasis-heat and microbial turbidity type),both Sangbai Shengfa liniment and minoxidil tincture present the similar clinical effect and have no significant impacts on the immune indexes,and no obvious toxic and side effects.

关 键 词：桑柏生发剂 斑秃 脂溢性脱发 郁热虫浊 淋巴细胞亚群 

分 类 号：R275.9[医药卫生—中西医结合]