硫酸特布他林联合布地奈德在慢阻肺急性加重期患者中的应用研究  

Application of Terbutaline Sulfate Combined with Budesonide in Patients with Acute Exacerbation of COPD

作　　者：王静[1] Wang Jing(Department of Respiratory Medicine,Tianjin No.3 Central Hospital Branch,Tianjin 300250)

机构地区：[1]天津市第三中心医院分院呼吸科,天津300250

出　　处：《数理医药学杂志》2020年第11期1660-1662,共3页Journal of Mathematical Medicine

摘　　要：目的:观察硫酸特布他林联合布地奈德在慢阻肺急性加重期患者中的应用效果。方法:采用随机数表法,将2018年9月~2019年9月某院收治的64例慢阻肺急性加重期患者分为对照组和观察组各32例。两组均采取常规治疗,在此基础上予以布地奈德治疗对照组,予以硫酸特布他林联合布地奈德治疗观察组,两组均治疗1周,对比两组治疗前及治疗1周时炎性因子水平、肺功能与血气指标。结果:治疗后观察组血清白介素-6(IL-6)、C反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)及γ干扰素(IFN-γ)水平均低于对照组,差异有统计学意义(P<0.05);治疗后观察组用力肺活量(FVC)、最大呼气压(MEP)、最高呼气流速(PEF)及最大吸气压(MIP)水平均高于对照组,差异有统计学意义(P<0.05);治疗后观察组动脉二氧化碳分压(PaCO2)水平低于对照组,动脉血氧分压(PaO2)及动脉血氧饱和度(SaO2)高于对照组,差异有统计学意义(P<0.05)。结论:硫酸特布他林联合布地奈德治疗可改善慢阻肺急性加重期患者炎性因子水平、肺功能与血气指标,效果较好。Objective:To observe the effect of terbutaline sulfate combined with budesonide in patients with acute exacerbation of chronic obstructive pulmonary disease.Methods:Using the random number table method,64 patients with acute exacerbation of chronic obstructive pulmonary disease admitted to a hospital from September 2018 to September 2019 were divided into 2 groups,with 32 cases in each group.Both groups were treated with conventional treatment.On this basis,the control group was treated with budesonide,and the observation group was treated with terbutaline sulfate combined with budesonide.Both groups were treated for 1 week.The levels of inflammatory factors,lung function and blood gas indexes were compared between the two groups before treatment and 1 week after treatment.Results:After treatment,the serum levels of interleukin-6(IL-6),C-reactive protein(CRP),tumor necrosis factor-α(TNF-α)and interferon-γ(IFN-γ)in the observation group were lower than those in the control group,with statistically significant difference(P<0.05);After treatment,the forced vital capacity(FVC),maximum expiratory pressure(MEP),maximum expiratory flow rate(PEF)and maximum inspiratory pressure(MIP)levels of the observation group were higher than those of the control group,and the difference was statistically significant(P<0.05);After treatment,the arterial partial pressure of carbon dioxide(PaCO 2)in the observation group was lower than that in the control group,and the arterial partial pressure of oxygen(PaO 2)and arterial oxygen saturation(SaO 2)were higher than those in the control group,the difference was statistically significant(P<0.05).Conclusion:The application of terbutaline sulfate combined with budesonide in the treatment of patients with acute exacerbation of COPD can improve the levels of inflammatory factors,lung function and blood gas indexes,with better effect.

关 键 词：慢性阻塞性肺疾病 急性加重期 布地奈德 硫酸特布他林 肺功能 

分 类 号：R563[医药卫生—呼吸系统]