超声引导下微波消融与手术切除对良性甲状腺结节患者炎性应激反应及甲状腺功能的影响  

Effects of Ultrasound-guided Microwave Ablation and Surgical Resection on Inflammatory Stress Response and Thyroid Function in Patients with Benign Thyroid Nodules

作　　者：于永洋[1] 张福星[1] 刘昭晖[1] 黄耘[1] YU Yongyang;ZHANG Fuxing;LIU Zhaohui;HUANG Yun(The First Affiliated Hospital of Xiamen University,Xiamen 361000,China)

机构地区：[1]厦门大学附属第一医院,福建厦门361000

出　　处：《中国医学创新》2020年第30期120-123,共4页Medical Innovation of China

摘　　要：目的:观察超声引导下微波消融与手术切除对良性甲状腺结节患者炎性应激反应及甲状腺功能的影响。方法:选择2018年1月-2019年4月本院治疗的良性甲状腺结节患者82例。按随机数字表法将其分为观察组和对照组,各41例。对照组采用手术切除治疗,观察组采用超声引导下微波消融术治疗。比较两组炎性应激反应指标[肿瘤坏死因子-α(TNF-α)、白介素-6(IL-6)]、甲状腺功能[促甲状腺激素(TSH)、游离三碘甲腺原氨酸(FT3)、总甲状腺素(TT4)]及并发症发生情况。结果:术前,两组TNF-α、IL-6、TSH、FT3、TT4水平比较,差异均无统计学意义(P>0.05)。术后,观察组TNF-α、IL-6、TSH水平均低于对照组,差异均有统计学意义(P<0.05)。术后,观察组FT3、TT4均高于对照组,差异均有统计学意义(P<0.05)。观察组并发症发生率为4.88%,低于对照组的19.51%,差异有统计学意义(P<0.05)。结论:超声引导下微波消融术用于良性甲状腺结节治疗中并发症少且对甲状腺功能影响小,能减轻炎性应激反应,可为良性甲状腺结节治疗方案的制定提供依据。Objective:To observe the effects of ultrasound-guided microwave ablation and surgical resection on inflammatory stress response and thyroid function in patients with benign thyroid nodules.Method:Eighty-two patients with benign thyroid nodules treated in our hospital from January 2018 to April 2019 were selected.According to the random number table method,they were divided into observation group and control group,41 cases in each group.The control group was treated with surgical resection,the observation group was treated with ultrasound-guided microwave ablation.Inflammatory stress response indicators[tumor necrosis factor-α(TNF-α),interleukin-6(IL-6)],thyroid function[thyroid stimulating hormone(TSH),free triiodothyronine(FT3),total thyroxine(TT4)]and complications were compared between the two groups.Result:Before operation,the levels of TNF-α,IL-6,TSH,FT3 and TT4 in the two groups were not significantly diffierences(P>0.05).After surgery,the levels of TNF-α,IL-6 and TSH in the observation group were all lower than those in the control group,with statistically significant differences(P<0.05).After surgery,FT3 and TT4 in the observation group were both higher than those in the control group,the differences were statistically significant(P<0.05).The complication rate in the observation group was 4.88%,it was lower than 19.51%in the control group,there were statistically significant difference(P<0.05).Conclusion:Ultrasound-guided microwave ablation in the treatment of benign thyroid nodules has fewer complications and less impact on thyroid function,which can reduce inflammatory stress response,and can provide a basis for the formulation of treatment plans for benign thyroid nodules.

关 键 词：良性甲状腺结节 超声引导下微波消融 手术切除 炎性应激反应 甲状腺功能 

分 类 号：R653[医药卫生—外科学]