创面修复软膏促进大鼠创面愈合的药效学研究  

Study on the pharmacodynamics of wound repair ointment in promoting wound healing in rats

作　　者：杨盟 陈敏燕[1] 王蓉[1] 韩璐[1] 原永芳[1] YANG Meng;CHEN Minyan;WANG Rong;HAN Lu;YUAN Yongfang(Department of Pharmacy,Shanghai Ninth People’s Hospital Affiliated to School of Medicine,Shanghai Jiao Tong University,Shanghai 200011,China)

机构地区：[1]上海交通大学医学院附属第九人民医院药剂科,上海200011

出　　处：《药学服务与研究》2020年第5期359-363,共5页Pharmaceutical Care and Research

基　　金：上海市科学技术委员会基金(19401900400,17401900800)。

摘　　要：目的:进行创面修复软膏促进大鼠创面愈合的药效学研究。方法:选取健康SD大鼠,分别建立一般创面模型和烧烫伤创面模型,清洁创面后给药,用无菌纱布覆盖,医用胶带固定,每天换药至所有创面愈合。考察大鼠创面愈合时间和创面愈合率,根据炎性渗出物、肉芽组织再生及上皮再生情况对大鼠烫伤部位的创面愈合情况进行评分,制作苏木精-伊红(HE)染色切片观察创面病理组织学变化。结果:创面修复软膏能够缩短创面愈合和创面结痂所需要的时间,缩小创面面积,而且能够减轻皮肤瘢痕增生。结论:创面修复软膏对创面具有明显的促进愈合作用。Objective:To study pharmacodynamics of the wound repair ointment in promoting wound healing in rats.Methods:Healthy SD rats were selected to establish general wound model and burn and scald wound model.After cleaning,drugs were administrated,wound surfaces were covered with sterile gauze,fixed with medical tape,and dressing changed daily until all wounds healed.Then,healing time and healing rate were investigated.Evaluations on the wound surface healing of the affected sites were made in accordance with the inflammatory exudate,granulation tissue regeneration and epithelial regeneration.Histopathological changes of the wound surfaces were observed by hematoxylin-eosin(HE)staining.Results:The wound repair ointment could shorten the time required for wound healing and wound scabbing,reduce wound size,and alleviate skin scar hyperplasia.Conclusion:The wound repair ointment has obvious effect on the promotion of wound healing.

关 键 词：创面修复软膏 创面愈合 一般创面模型 烧烫伤创面模型 药效学 

分 类 号：R965[医药卫生—药理学]