沙尘天气致呼吸系统损伤及其机制的研究进展  

Research progress of respiratory system injury caused by dust weather and its mechanism

作　　者：李怡[1] 厚银环 桑迎竹 罗万银 肖晓辉(综述)[2] 雷丰丰(审校)[2] LI Yi;HOU Yin-huan;SANG Ying-zhu(Cadres′ Ward in the Department of Respiration, Gansu Provincial Hospital, Lanzhou 730000, China)

机构地区：[1]甘肃省人民医院干部呼吸科,兰州730000 [2]甘肃省人民医院呼吸科,兰州730000 [3]静宁县人民医院呼吸科,甘肃744000 [4]中国科学院西北生态环境资源研究院沙漠与沙漠化重点实验室,兰州730000

出　　处：《中国临床新医学》2020年第10期1056-1061,共6页CHINESE JOURNAL OF NEW CLINICAL MEDICINE

基　　金：国家自然科学基金项目(编号:41161019,41461020,41961016)。

摘　　要：土地沙漠化造成沙尘天气频繁发生,使大气细颗粒物浓度明显升高,引起以呼吸系统为主的多系统损害,受到政府和公众的关注。沙尘天气增加人群呼吸系统疾病的发病率、住院率及相应肺功能、胸片改变等。动物实验证实沙尘细颗粒物暴露导致肺组织炎性损伤、慢性期形成沙尘肺纤维化等。目前认为免疫炎症反应、氧化应激等是沙尘细颗粒物对呼吸系统损伤的主要机制。因此深入研究沙尘细颗粒物对呼吸系统的损伤作用及其机制,为有效预防与治疗人类相关疾病提供理论依据。Land desertification causes dust weather frequently,which increases the concentration of fine particulate matter(PM)in the atmosphere and causes multi-system damage mainly to the respiratory system,attracting the attention of the government and the public.Dust weather increases the incidence of respiratory diseases,hospitalization rate and causes the corresponding lung function and chest radiograph changes in the population.Animal experiments have confirmed that exposure to PM causes the inflammatory damage of the lung tissues,and the formation of sand pneumoconiosis fibrosis in the chronic stage.At present,it is believed that immune inflammatory response and oxidative stress are the main mechanisms of respiratory system injury caused by dust PM.Therefore,an in-depth study on the respiratory system injury effect of dust PM and its mechanisms provides a theoretical basis for the effective prevention and treatment of human related diseases.

关 键 词：沙尘天气 沙尘细颗粒物 呼吸系统损伤 机制 

分 类 号：R563[医药卫生—呼吸系统] R122[医药卫生—内科学]