老年2型糖尿病患者下肢血管病变和血清维生素E水平的关系  

The Relationship between Lower Limb Vascular Disease and Serum Vitamin E Level in Elderly Patients with Type 2 Diabetes

作　　者：高佳 罗镧[1] GAO Jia;LUO Lan(Department of Geriatrics,Ruici Hospital,Nantong University,Nantong,Jiangsu Province,226000 China)

机构地区：[1]南通大学附属瑞慈医院老年科,江苏南通226000

出　　处：《糖尿病新世界》2020年第19期34-37,共4页Diabetes New World Magazine

摘　　要：目的探讨老年2型糖尿病患者的血清维生素E水平与其下肢血管病变的关系。方法选择2017年2月—2018年6月该院收治的170例2型糖尿病患者,其中130例T2DM患者以及对照组40例。根据彩色多普勒超声结果,将T2DM患者分为单纯T2DM不合并下肢血管病变组40例,以及T2DM合并下肢血管病变组90例(再分为轻度、中度、重度3个亚组)。采用高效液相色谱法(HPLC)测定血清中维生素E水平。结果①T2DM伴下肢血管病变组的血清维生素E水平显著低于单纯T2DM无下肢血管病变组及非T2DM对照组,差异有统计学意义(P<0.05)。单纯T2DM无下肢血管病变组的血清维生素E水平也低于非T2DM对照组,差异有统计学意义(P<0.05)。②T2DM伴下肢血管病变组中3个亚组相比,重度病变组血清维生素E水平低于中度组和轻度组,中度组维生素E水平低于轻度组,差异有统计学意义(P<0.05)。③T2DM组血清维生素E水平与hs-CRP呈负相关。结论老年T2DM患者的血清维生素E水平下降,hs-CRP升高,其幅度与T2DM合并下肢血管病变的程度相关。血清维生素E水平降低可能是T2DM下肢血管病变发生和发展的因素。Objective To investigate the relationship between serum vitamin E level in elderly patients with type 2 diabetes and the vascular disease of the lower extremities.Methods Selected 170 cases patients with type 2 diabetes admitted to the hospital from February 2017 to June 2018,including 130 cases patients with T2DM and 40 cases patients in the control group.According to the results of color Doppler ultrasound,patients with T2DM were divided into T2DM alone without lower extremity vascular disease group of 40 cases,and T2DM combined with lower extremity vascular disease group of 90 cases(subdivided into three subgroups of mild,moderate,and severe).High performance liquid chromatography(HPLC)was used to determine the level of vitamin E in serum.Results 1.The serum vitamin E level of the T2DM group with lower extremity vascular disease was significantly lower than that of the T2DM group without lower extremity vascular disease and the non-T2DM control group,the difference was statistically significant(P<0.05).The serum vitamin E level of the T2DM group without lower limb vascular disease was also lower than that of the non-T2DM control group,the difference was statistically significant(P<0.05).2.Compared with the three subgroups in the T2DM with lower extremity vascular disease group,the serum vitamin E level of the severe disease group was lower than the moderate group and the mild group,and the vitamin E level of the moderate group was lower than the mild group.3.Serum vitamin E level in T2DM group was negatively correlated with hs-CRP,the difference was statistically significant(P<0.05).Conclusion The serum vitamin E level of elderly patients with T2DM decreased,and the hs-CRP increased,the magnitude of which was related to the degree of T2DM combined with lower extremity vascular disease.Decreased serum vitamin E level may be a factor in the occurrence and development of T2DM lower limb vascular disease.

关 键 词：老年 2型糖尿病 下肢血管病变 血清维生素E 

分 类 号：R587.1[医药卫生—内分泌]