病毒性脑炎患儿神经元特异性烯醇化酶、髓鞘碱性蛋白、S-100蛋白水平及临床意义  

Levels of neuron-specific enolase,myelin basic protein,S-100 protein and their clinical significance in children with viral encephalitis

作　　者：方思思 罗兰[1] 周海银[1] 隆彩霞[1] FANG Sisi;LUO Lan;ZHOU Haiyin;LONG Caixia(Second General Department of Emergency,Hunan Children′s Hospital,Changsha,Hunan,410001)

机构地区：[1]湖南省儿童医院急诊综合二科,湖南长沙410001

出　　处：《实用临床医药杂志》2020年第17期89-91,95,共4页Journal of Clinical Medicine in Practice

摘　　要：目的分析病毒性脑炎患儿脑脊液和血清中神经元特异性烯醇化酶(NSE)、髓鞘碱性蛋白(MBP)和S-100蛋白(S-100)水平。方法将205例病毒性脑炎患儿设为观察组(按不同病情严重程度分为轻症组112例和重症组93例),将同期门诊体检的200名健康儿童设为对照组,比较不同组别受检儿童脑脊液和血清中NSE、MBP、S-100水平。结果观察组入院24 h脑脊液和血清中NSE、MBP、S-100水平高于对照组,且轻症组上述指标水平低于重症组,差异均有统计学意义(P<0.05);血清NSE、MBP、S-100联合检测的敏感度(91.22%)、准确度(89.14%)均高于单项指标检测,差异有统计学意义(P<0.05),联合检测与单项检测的特异度比较,差异无统计学意义(P>0.05)。结论脑脊液和血清中NSE、MBP、S-100水平与病毒性脑炎患儿病情密切相关,血清NSE、MBP、S-100联合检测具有较高的诊断价值。Objective To analyze the levels of neuron-specific enolase( NSE),myelin basic protein( MBP),S-100 protein( S-100) in cerebrospinal fluid and serum of children with viral encephalitis. Methods A total of 205 viral encephalitis cases were selected as observation group,which were subdivided into mild group( n = 112) and severe group( n = 93) according to the severity of the disease. Another 200 healthy children in the same period were selected as control group. The levels of NSE,MBP and S-100 in the cerebrospinal fluid and serum of children in two groups were detected and compared. Results The levels of NSE,MBP and S-100 in cerebrospinal fluid and serum of the observation group at 24 h after admission were significantly higher than those of the control group,while were significantly lower in the mild group than those in the severe group( P < 0. 05). The sensitivity and accuracy of combined detection of NSE,MBP and S-100 were 91. 22% and 89. 14% respectively,which were significantly higher than those detected by single detection( P < 0. 05). There was no significant difference in the specificity between combined detection and single detection( P >0. 05). Conclusion The levels of NSE,MBP and S-100 in cerebrospinal fluid and serum are closely related to the disease condition of children with viral encephalitis,and their combined detection is of significant diagnostic value.

关 键 词：病毒性脑炎 脑脊液 神经元特异性烯醇化酶 髓鞘碱性蛋白 S-100蛋白 

分 类 号：R512.3[医药卫生—内科学]