大剂量辛伐他汀对老年高血压合并高脂血症患者的治疗效果观察  

Effects of high doses of simvastatin in treating elderly patients with hypertension and hyperlipidemia

作　　者：雷要军 LEI Yaojun(Pharmacy Department,Huaiyang County People′s Hospital of Henan Province,Zhoukou,Henan,466700)

机构地区：[1]河南省淮阳县人民医院药剂科,河南周口466700

出　　处：《实用临床医药杂志》2020年第18期64-67,共4页Journal of Clinical Medicine in Practice

摘　　要：目的观察老年高血压合并高脂血症患者应用大剂量辛伐他汀治疗的临床效果。方法选取84例老年高血压合并高脂血症患者作为研究对象,采用随机数字表法分为对照组与观察组,每组42例。对照组采用小剂量辛伐他汀(20 mg/次,1次/d)口服治疗,观察组采用大剂量辛伐他汀(40 mg,1次/d)口服治疗,比较2组患者的血压水平、血脂水平、疗效和不良反应发生率。结果治疗前,2组血压水平和甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)水平比较,差异无统计学意义(P>0.05);治疗后,观察组收缩压为(116.82±11.46)mmHg,舒张压为(86.13±7.62)mmHg,分别低于对照组的(124.72±12.06)、(90.36±6.05)mmHg,差异有统计学意义(P<0.05);治疗后,观察组TG、TC、LDL-C水平低于对照组,HDL-C水平高于对照组,差异有统计学意义(P<0.05);观察组治疗总有效率为95.24%,高于对照组的78.57%,差异有统计学意义(P<0.05);2组不良反应发生率差异无统计学意义(P>0.05)。结论老年高血压合并高脂血症患者应用大剂量辛伐他汀治疗,能够明显调控血脂水平,降低血压水平,提升疗效,且安全性良好。Objective To observe the clinical effect of high doses of simvastatin in treating elderly patients with hypertension and hyperlipidemia. Methods A total of 84 elderly patients with hypertension combined with hyperlipidemia were selected and divided into two groups by random number table method. The control group (n = 42) orally administrated small dose of simvastatin (20 mg,once daily),while the observation group (n = 42) was given high dose of simvastatin (40 mg,once daily)for oral administration. Blood pressure,blood lipid,efficacy and incidence of adverse reactions of two groups were compared. Results There were no significant differences in blood pressure,triglyceride (TG),total cholesterol (TC),low-density lipoprotein (LDL-C) and high-density lipoprotein cholesterol (HDL-C) between the two groups before treatment (P > 0. 05). After treatment,systolic blood pressure and diastolic blood pressure in the observation group were (116. 82 ± 11. 46) mmHg and (86. 13 ±7. 62) mmHg,respectively,which were significantly lower than (124. 72 ± 12. 06) mmHg and (90. 36 ± 6. 05) mmHg in the control group (P < 0. 05). After treatment,TG,TC,LDL-C levels were significantly lower than those of control group,and HDL-C level was significantly higher than that of control group (P < 0. 05). The total effective rate of the observation group was significantly higher than that of the control group (95. 24% versus 78. 57%,P < 0. 05). There was no significant difference in the incidence of adverse reactions between two groups (P > 0. 05). Conclusion High doses of simvastatin in treating elderly patients with hypertension and hyperlipidemia can significantly regulate the level of blood lipid,reduce the level of blood pressure,and improve curative efficacy,and it has higher safety.

关 键 词：老年 高血压 高脂血症 大剂量 辛伐他汀 安全性 

分 类 号：R544.1[医药卫生—心血管疾病]