异种(猪)脱细胞真皮基质敷料联合创面薄化修复深Ⅱ度烧伤创面对机体炎症水平的影响  

Effect of Xenogeneic (Pig) Acellular Dermal Matrix Dressing Combined with WoundThinning on Inflammatory Level in Patients with Deep Second Degree Burns

作　　者：万能[1] 杨卫玺[1] 程宏宇[1] 吴冬冬 WAN Neng;YANG Wei-xi;CHENG Hong-yu;WU Dong-dong(Department of Burn and Plastic Surgery,the Affiliated Huai`an No.1 Hospital of Nanjing Medical University,Huai`an 223300,Jiangsu,China)

机构地区：[1]南京医科大学附属淮安第一医院烧伤整形科,江苏淮安223300

出　　处：《中国美容医学》2020年第10期57-60,共4页Chinese Journal of Aesthetic Medicine

摘　　要：目的:探讨异种(猪)脱细胞真皮基质敷料联合创面薄化修复深Ⅱ度烧伤创面对患者炎症水平的影响。方法:选取笔者医院2017年8月-2019年4月收治的70例深Ⅱ度烧伤患者,依据随机数表法将患者分为观察组及对照组,两组各35例。观察组患者行异种(猪)脱细胞真皮基质敷料联合创面薄化,对照组患者行创面薄化。对比两组患者术前及术后24h血清TNF-α、IL-10及IL-6水平及不良反应发生率等情况。结果:两组患者治疗后TNF-α及IL-6水平较治疗前显著降低,IL-10水平较治疗前显著升高,差异有统计学意义(P<0.05);且治疗后观察组TNF-α及IL-6水平显著低于对照组,IL-10水平显著高于对照组,差异有统计学意义(P<0.05)。观察组并发症发生率为5.71%低于对照组的48.57%,差异有统计学意义(χ2=16.254,P<0.001)。观察组无瘢痕及瘢痕增生率为34.29%vs 65.71%,对照组无瘢痕及瘢痕增生率为5.71%vs 94.29%,组间比较差异有统计学意义(χ2=8.924,P=0.003)。观察组患者换药次数及愈合时间均少于对照组,差异有统计学意义(P<0.05)。结论:异种(猪)脱细胞真皮基质敷料联合创面薄化修复深Ⅱ度烧伤患者可有效降低机体血清TNF-α及IL-6的水平,增加血清抗炎因子IL-10水平,减轻患者伤后全身炎症反应综合征,减少严重并发症的发生。Objective To investigate the effect of xenogeneic(pig)acellular dermal matrix dressing combined with thinning wounds on the inflammation level in patients with deep second degree burns.Methods A total of 70 patients with deep second degree burns treated in our hospital from August 2017 to April 2019 were selected, and the patients were divided intoobservation group and control group according to the random number table method, with 35 patients in each group. Patientsin the observation group were treated with xenogeneic (pig) decellularized dermal matrix dressings combined with thinningof the wound, and patients in the control group were treated with thinning. The serum levels of TNF-α, IL-10 and IL-6 andthe incidence of adverse reactions were compared between the two groups of patients before and after surgery. Results Aftertreatment, the levels of TNF-α and IL-6 in the two groups were significantly lower than before treatment, the differences werestatistically significant (P <0.05). And the levels of IL-10 were significantly higher than before treatment (P <0.05). The levelsof TNF-α and IL-6 in the observation group were significantly lower than those in the control group, and the level of IL-10 inthe observation group was significantly higher than that in the control group (P <0.05). The complication rate of the observationgroup was 5.71%, which was lower than 48.57% of the control group (χ2=16.254, P <0.001). The rate of no scar and scarhyperplasia in the observation group was 34.29% vs 65.71%, and that of the control group was 5.71% vs 94.29%, the differencewas statistically significant (χ2=8.924, P =0.003). The times of dressing change and healing time in the observation group wereless than those in the control group (P <0.05). Conclusion Xenogeneic (pig) acellular dermal matrix dressing combined withthinning wounds can effectively reduce the levels of serum TNF-α and IL-6 in patients with deep second degree burns, increaseserum anti-inflammatory factor IL-10 levels, and reduce systemic inflammation re

关 键 词：异种(猪)脱细胞真皮基质敷料 创面薄化 烧伤 深Ⅱ度 炎症水平 瘢痕 

分 类 号：R644[医药卫生—外科学]