自身免疫性甲状腺疾病患者血清25-(OH)D表达水平与白癜风的相关性分析  

Correlation between Serum 25-(OH)D Expression Level and Vitiligo in Patients withAutoimmune Thyroid Disease

作　　者：丁钰[1] 黄忠奎[1] 胡秀玲 DING Yu;HUANG Zhong-kui;HU Xiu-ling(Department of Dermatology,Mianyang Central Hospital,Mianyang 621000,Sichuan,China;Department of Dermatology,Zitong County People's Hospital,Mianyang 622150,Sichuan,China)

机构地区：[1]绵阳市中心医院皮肤科,四川绵阳621000 [2]梓潼县人民医院皮肤科,四川绵阳622150

出　　处：《中国美容医学》2020年第10期111-114,共4页Chinese Journal of Aesthetic Medicine

摘　　要：目的:探究自身免疫性甲状腺疾病(AITD)患者血清25羟维生素D[25-(OH)D]表达水平与白癜风的相关性。方法:前瞻性选择2018年12月-2019年12月笔者医院收治的125例自身免疫性甲状腺疾病患者,其中桥本甲状腺炎(HT)51例为HT组,Graves病(GD)74例为GD组,同期体检健康者50例为对照组,比较HT组、GD组、对照组血清25-(OH)D水平,根据自身免疫性甲状腺疾病患者是否合并白癜风分为非白癜风组(n=87)与白癜风组(n=38),比较非白癜风组与白癜风组血清25-(OH)D水平,采用Spearman相关分析血清25-(OH)D水平与自身免疫性甲状腺疾病伴白癜风的相关性,比较不同临床病理特征的自身免疫性甲状腺疾病伴白癜风患者血清25-(OH)D水平。结果:HT组、GD组血清25-(OH)D水平显著低于对照组,差异有统计学意义(P<0.05);GD组血清25-(OH)D水平较HT组比较差异无统计学意义(P>0.05);白癜风组血清25-(OH)D水平显著低于非白癜风组,差异有统计学意义(P<0.05);血清25-(OH)D水平与自身免疫性甲状腺疾病伴白癜风呈负相关(P<0.05);不同性别、分型、分期、受累面积的自身免疫性甲状腺疾病伴白癜风患者血清25-(OH)D水平比较差异无统计学意义(P>0.05);不同年龄、病程的自身免疫性甲状腺疾病伴白癜风患者血清25-(OH)D水平差异具有统计学意义(P<0.05)。结论:自身免疫性甲状腺疾病患者血清25-(OH)D呈低表达,其表达水平与白癜风呈负性相关,血清25-(OH)D水平检测对自身免疫性甲状腺疾病伴白癜风具有重要临床指导意义。Objective To investigate the correlation between serum 25-hydroxy vitamin D[25-(OH)D]expression level and vitiligo in patients with autoimmune thyroid disease(AITD).Methods 125 AITD patients in our hospital from December 2018 to December 2019 were enrolled prospectively,including 51 cases of HT patients(HT group)and 74 cases of GD patients(GD group),meanwhile,another 50 healthy individuals were enrolled as control group.AITD patients were divided into two subgroups according to the presence or absence of vitiligo,non-vitiligo group(n=87)and vitiligo group(n=38).25-(OH)D levels were compared between groups and subgroups.Correlation between 25-(OH)D level and vitiligo was analyzed by spearman correlation analysis.Then the serum 25-(OH)D levels were compared among AITD combined with vitiligo patients with different clinicopathological characteristics.Results 25-(OH)D level of HT group and GD group was lower than that of control group(P<0.05),while no difference was found between GD group and control group(P>0.05).25-(OH)D level of vitiligo group was lower than that of non-vitiligo group(P<0.05).Serum 25-(OH)D level was negatively correlated with the incidence rate of vitiligo in AITD patients(P<0.05).Serum 25-(OH)D level of AITD patients with vitiligo had no significant difference among patients with different gender,types,stages and lesion areas(P>0.05),while the levels of 25-(OH)D showed significant difference of patients with different ages and disease courses(P<0.05).Conclusion Serum 25-(OH)D level is down-regulated in AITD patients,and its expression levels are negatively correlated with the incidence rate of vitiligo;so the detection of serum 25-(OH)D level has high clinical guidance for the treatment of ITD combined with vitiligo.

关 键 词：自身免疫性甲状腺疾病 25-羟维生素D 表达水平 白癜风 临床病理特征 相关性 

分 类 号：R581[医药卫生—内分泌]