基于N⁃乙酰⁃L⁃半胱氨酸修饰的ZnFe2O4@SiO2纳米材料手性识别酪氨酸对映异构体  

Chiral Discrimination Tyrosine Enantiomers Based on N⁃Acetyl⁃L⁃cysteine Modified ZnFe2O4@SiO2 Nanoparticles

作　　者：陈少凯 李新 郭晨晨 魏旖儇 袁赛薇 宋会花[1] CHEN Shao-Kai;LI Xin;GUO Chen-Chen;WEI Yi-Xuan;YUAN Sai-Wei;SONG Hui-Hua(College of Chemistry and Material Science,Hebei Normal University,Shijiazhuang 050024,China)

机构地区：[1]河北师范大学化学与材料科学学院,石家庄050024

出　　处：《无机化学学报》2020年第11期2169-2178,共10页Chinese Journal of Inorganic Chemistry

基　　金：河北省自然科学基金(No.B2018205152);河北省引进留学人员基金(No.CL201715)资助项目。

摘　　要：我们将N⁃乙酰⁃L⁃半胱氨酸(NALC)修饰于ZnFe2O4@SiO2纳米材料表面,制备了一种新型的手性纳米复合物(ZnFe2O4@SiO2⁃NALC),该材料能够简便、快速及高选择性地识别手性酪氨酸(Tyr)对映体。利用X射线粉末衍射(XRD)、红外光谱(FT⁃IR)、能量色散X射线光谱(EDS)、扫描电子显微镜(SEM)、高分辨率透射电子显微镜(HRTEM)和振动样品磁力计(VSM)等一系列表征手段对首次合成出的ZnFe2O4@SiO2⁃NALC进行测试表征,并将其应用于对手性识别领域的探究。实验结果表明,利用光谱技术(紫外-可见光谱和荧光光谱),ZnFe2O4@SiO2⁃NALC可对Tyr对映异构体进行手性识别。此外,我们进一步对Tyr浓度和pH值等实验参数进行了优化。N⁃acetyl⁃L⁃cysteine(NALC)functionalized ZnFe2O4@SiO2(ZnFe2O4@SiO2⁃NALC)was synthesized and exhibited simplicity,rapidity and high selectivity in the separation of chiral tyrosine(Tyr)enantiomers.The chiral nanocomposite of ZnFe2O4@SiO2⁃NALC was characterized by X⁃ray powder diffraction(XRD),infrared spectroscopy(FT⁃IR),energy dispersive X⁃ray spectroscopy(EDS),scanning electron microscopy(SEM),high resolution transmis⁃sion electron microscopy(HRTEM)and vibrating sample magnetometer(VSM).This is the first synthesis of ZnFe2O4@SiO2⁃NALC for chiral recognition.The proposed optical spectroscopic techniques(UV⁃Vis spectrum and fluorescence spectra)showed excellent enantiospecificity for Tyr enantiomers.Furthermore,the experimental param⁃eters such as the Tyr concentration and the pH values were optimized.

关 键 词：手性识别 ZnFe2O4@SiO2⁃NALC 手性纳米粒子 酪氨酸 

分 类 号：O611.65[理学—无机化学]