基于系统药理学探究新型冠状病毒肺炎中医病机  

Exploration on TCM Pathogenesis of COVID-19 Based on Systematic Pharmacology

作　　者：刘铁钢[1] 白辰[1] 刘邵阳[1] 黄羚[1] 董斐[1] 赵岩松[1] 于河[1] 刘果[1] 林燕[1] 谷晓红[1] LIU Tiegang;BAI Chen;LIU Shaoyang;HUANG Ling;DONG Fei;ZHAO Yansong;YU He;LIU Guo;LIN Yan;GU Xiaohong(Beijing University of Chinese Medicine,Beijing 100029,China)

机构地区：[1]北京中医药大学,北京100029

出　　处：《中国中医药信息杂志》2020年第11期99-105,共7页Chinese Journal of Information on Traditional Chinese Medicine

基　　金：国家重点研发计划(2018YFC1704100、2018YFC1704101);北京市科技新星项目(Z181100006218083)。

摘　　要：目的运用系统药理学的“症状网络映射”方法,对《新型冠状病毒肺炎诊疗方案(试行第七版)》中各证候的临床症状进行映射分析,探究新型冠状病毒肺炎的中医病机,为该病的中医防治提供思路和依据。方法提取新型冠状病毒肺炎各证候的最小单位症状,在SymMap数据库中检索对应的中药,构建“证候-症状-中药”数据库;对数据库中的高频中药进行分析,统计药物的性味归经,用Cytoscape3.7.2构建“证候-症状-中药-性味归经”网络图。结果寒湿郁肺证对应138味中药,以性温,味苦、辛,归肺、脾、胃经为主;湿热蕴肺证对应85味中药,以性温,味苦、甘,归肺、脾、胃经为主;湿毒郁肺证对应135味中药,以性温、寒,味苦、甘、辛,归肺、脾、胃经为主;寒湿阻肺证对应57味中药,以性温,味苦、甘、辛,归肺、脾、胃经为主;疫毒闭肺证对应155味中药,以性温、寒,味苦、甘、辛,归肺、脾、胃、心经为主;气营两燔证对应112味中药,以性寒,味苦、甘,归肺、胃、心、肝经为主;内闭外脱证对应25味中药,以性温、凉,味苦、甘,归肺、脾、心、肾、肝经为主;肺脾气虚证对应48味中药,以性温,味甘,归肺、脾经为主;气阴两虚证对应55味中药,以性温、平,味甘,归肺、脾、心、肾经为主。结论新型冠状病毒各证候的临床症状映射药物以性温,味辛、甘、苦,归肺、脾经为主,提示主要病位在肺、脾,湿邪阻滞病机存在于各阶段,其中轻型、普通型表现为湿兼寒,重型、危重型、恢复期表现为湿兼热。气虚病机见于疾病各阶段,治疗中应注意顾护正气,并根据邪实与正虚的对比情况立法用药。Objective To map analyze the clinical symptoms of each syndrome in COVID-19 Diagnosis and Treatment Plan(Trial Seventh Edition)using the“symptom network mapping”method of systematic pharmacology;To explore the TCM pathogenesis of COVID-19;To provide ideas and basis for the prevention and treatment of COVID-19 in TCM.Methods The smallest unit symptoms of each syndrome of COVID-19 were extracted and the corresponding Chinese materia medica in SymMap database were retrieved to construct the“syndrome-symptom-Chinese materia medica”database;the high-frequency Chinese materia medica appearing in the database was analyzed;properties,tastes and meridian tropism were collected;the network diagram of“syndrome-symptom-Chinese materia medica-properties,tastes and meridian tropism”were constructed with Cytoscape 3.7.2.Results The syndrome of cold-dampness stagnating the lung corresponded to 138 kinds of Chinese materia medica,which were mainly warm in property,bitter and pungent in taste,and belonged mainly to the meridians of lung,spleen and stomach;the syndrome of dampness-heat accumulating in the lung corresponded to 85 kinds of Chinese materia medica,which were mainly warm in property,bitter and sweet in taste,and belonged mainly to the meridians of lung,spleen and stomach;the syndrome of dampness-toxin stagnation of the lung corresponded to 135 kinds of Chinese materia medica,which were mainly warm and cold in property,bitter,sweet and pungent in taste,and belonged mainly to the meridians of lung,spleen and stomach;the syndrome of cold-dampness blocking the lung corresponded to 57 kinds of Chinese materia medica,which were mainly warm in property,bitter,sweet and pungent in taste,and belonged mainly to the meridians of lung,spleen and stomach;the syndrome of closing the lung with epidemic toxin corresponded to 155 Chinese materia medica,which were mainly warm and cold in property,bitter,sweet and pungent in taste,and belonged mainly to the meridians of lung,spleen,stomach and heart;the syndrome of flaring hea

关 键 词：新型冠状病毒肺炎 诊疗方案 病机 系统药理学 

分 类 号：R259.631[医药卫生—中西医结合] R285[医药卫生—中医内科学]