磷酸氯喹在加速88例普通型新型冠状病毒肺炎患者核酸转阴的临床观察  

Chloroquine phosphate accelerates the conversion of nucleic acid to negative in 88 common COVID⁃19 pa⁃tients

作　　者：李娜[1] 谢甜[1] 魏晓芬 易省阳[1] 曹一秋[1] 蒋思怡 余雪涛[3] LI Na;XIE Tian;WEI Xiaofen;YI Shengyang;CAO Yiqiu;JIANG Siyi;YU Xuetao(Intensive Care Unit,Hainan General Hospital,Haikou 570311,China)

机构地区：[1]海南省人民医院重症医学科,海口570311 [2]深圳市第三人民医院重症医学科,广东深圳518100 [3]深圳市龙岗区人民医院重症医学科,广东深圳518100

出　　处：《实用医学杂志》2020年第20期2759-2762,共4页The Journal of Practical Medicine

摘　　要：目的探讨磷酸氯喹在加速普通型新型冠状病毒肺炎(coronavirus infectious disease 2019,COVID-19)患者核酸转阴的临床疗效。方法纳入2020年2月21日至3月8日在湖北省洪湖市第四人民医院确诊为普通型COVID-19的88例患者为研究对象。据知情同意原则分为治疗组(56例)和对照组(32例)。对两组患者入组后到鼻咽拭子核酸检测第1次转为阴性的时间、第1次转阴时病程天数、住院时间及住院费用进行比较,对治疗组用药前后血白细胞、淋巴细胞计数、肝肾功能进行比较,对比治疗组不同年龄段用药后核酸检测第1次转为阴性的时间、第1次转阴时病程天数。结果治疗组鼻咽拭子核酸检测第1次转阴时间、转阴时病程天数、住院时间及住院费用均明显小于对照组。出院后复查核酸检测复阳率明显低于对照组,差异有统计学意义(P<0.05)。治疗组用药前后血白细胞、淋巴细胞计数和肝肾功能差异均无统计学意义(P>0.05)。治疗组中A组(18岁≤年龄<35岁)、B组(35岁≤年龄<50岁)核酸检测第1次转为阴性的时间、第1次核酸检测转阴时病程天数均比C组(50岁≤年龄≤65岁)缩短,差异有统计学意义(P<0.05),A组与B组比较差异无统计学意义(P>0.05)。结论磷酸氯喹可以显著加快普通型COVID-19患者鼻咽拭子核酸检测转阴时间,缩短病程、住院时间,减少住院费用且核酸复阳发生率低,用药不良反应少,磷酸氯喹的疗效可能受年龄因素影响。Objective To investigate the clinical efficacy of chloroquine phosphate in accelerating the negative conversion of nucleic acid in patients with common COVID⁃19.Methods From February 21 to March 8,2020,88 patients with common COVID⁃19 in the Fourth People′s Hospital of Honghu City,Hubei Province,were included in the study.According to the principle of informed consent,they were divided into the treatment group(n=56)and the control group(n=32).We compared the time of first conversion to be negative of novel coronavirus nucleic acid and the total duration of sickness,hospital stay and hospitalization expenses between the groups.Within the treatment group we compared counts of white blood cells and lymphocytes,functions of liver and kidney before and after chloroquine phosphate treatment as well as the curative effect in patients of different age groups.Results Compared with the control group,the patients in the treatment group experienced signifi⁃cantly quicker negative conversion of COVID⁃19 nucleic acid,shorter hospital stay and less costs and the rate of recovered patients tested positive for the coronavirus was significantly lower(P<0.05).However,the counts of white blood cells and lymphocytes,functions of liver and kidney showed no significant differences before and after treatment with chloroquine phosphate.In the treatment group,the time when the nasopharyngeal swab nucleic acid test turned negative for the first time and the first time when the patients in the group aged between 18 to 35 years and the group aged between 35 and 50 years were significantly shorter than that in the group aged between 50 to 65(P<0.05).There was no significant difference between the groups aged 18 to 35 years and 35~50 years(P>0.05).Conclusion Chloroquine phosphate can significantly accelerate negative conversion of nucleic acid in patients with common COVID⁃19,reduce total duration of sickness and the length of hospital stay,lower the hospitalization expenses,reduce the rate of recovered patients tested positive aga

关 键 词：磷酸氯喹 新型冠状病毒肺炎 核酸 疗效 

分 类 号：R563.1[医药卫生—呼吸系统]