制造球形粒子的晶体聚结方法  

Granulation of spherical particles by crystal agglomeration method

作　　者：余畅游 何兵兵 刘岩博 侯宝红 陈明洋 龚俊波[1,3] YU Changyou;HE Bingbing;LIU Yanbo;HOU Baohong;CHEN Mingyang;GONG Junbo(State Key Laboratory of Chemical Engineering,School of Chemical Engineering and Technology,Tianjin University,Tianjin 300072,China;State Key Laboratory of Efficient Utilization for Low Grade Phosphate Rock and Its Associated Resources,Guiyang 550500,Guizhou,China;College of Chemistry and Chemical Engineering,Qinghai Nationalities University,Xining 810007,Qinghai,China)

机构地区：[1]天津大学化工学院,化学工程联合国家重点实验室,天津300072 [2]中低品位磷矿及其共伴生资源高效利用国家重点实验室,贵州贵阳550500 [3]青海民族大学化学化工学院,青海西宁810007

出　　处：《化工学报》2020年第11期4903-4917,共15页CIESC Journal

基　　金：中低品位磷矿及其共伴生资源高效利用国家重点实验室基金项目(WFKF2018-06);青海省自然科学基金项目(2019-ZJ-901)。

摘　　要：球形聚结技术能够在同一单元操作中耦合结晶和造粒过程以制备球形晶体。相比于传统流化床造粒技术,该技术具有工艺流程短,生产成本低,产品性能优良的优势,但是同时也面临研究方法不成熟、机理复杂、工业放大和特殊结晶器型等方面的挑战。总结了针对球形结晶产品的表征技术和关键产品指标,介绍了球形聚结过程机理、数学模型和新技术设备的研究进展,并提出关于深化机理、完善模型、开发新设备方面的新思路,最后对其在工业生产尤其是制药领域的发展进行了展望。Spherical agglomeration technology can prepare spherical agglomerates by coupling crystallization and granulation in a same unit operation,which has the advantages of short process,low production costs and excellent product performance compared with the traditional fluidized bed granulation technology.However,it is still challenging in characterization,mechanism,industrial scale-up,and special crystallizer type.Based on this,this article summarized the characterization techniques and key indicators of spherical crystallization products and mainly introduced the progress of mechanism,mathematical models,new technology and equipment of spherical agglomeration with new ideas for future research and development.Finally,it prospects the development in industrial production,especially in the pharmaceutical field.

关 键 词：结晶 团聚 流化床 表征 过程控制 新方法 

分 类 号：TQ028.5[化学工程]