糖尿病肾病患者血清抗AT1、α1、β1和M2受体自身抗体的分析  

Analysis of Serum anti-AT1,α1,β1 and M2 Receptor Autoantibodies in Patients with Diabetic Nephropathy

作　　者：黄思晓 魏正浩 林暖[1] HUANG Si-xiao;WEI Zheng-hao;LIN Nuan(Department of Laboratory Medicine,the First Hospital of Sanming,Sanming,Fujian Province,365000 China)

机构地区：[1]福建三明市第一医院检验科,福建三明365000

出　　处：《糖尿病新世界》2020年第17期172-174,共3页Diabetes New World Magazine

摘　　要：目的分析糖尿病肾病患者血清抗AT1、α1、β1和M2受体自身抗体特点,评估上述指标与肾功能损伤的关联。方法选取该院2017年1月—2019年1月收治的120例糖尿病患者,按照病情差异分为观察组和对照组,观察组见糖尿病肾病(n=60),对照组无糖尿病肾病(n=60)。另选取同期于该院接受健康体检的60名健康成年人,设为平行组。对比3组血清抗AT1、α1、β1和M2受体自身抗体阳性率。结果观察组患者血清抗AT1、α1、β1和M2受体自身抗体阳性率高于对照组、高于平行组(P<0.05);对照组患者血清抗AT1受体自身抗体阳性率高于平行组,α1、β1和M2受体自身抗体阳性率低于平行组(P<0.05)。结论糖尿病患者血清抗AT1、α1、β1和M2受体自身抗体阳性率异常,患者合并糖尿病肾病,血清抗AT1、α1、β1和M2受体自身抗体阳性率更高。Objective To analyze the characteristics of serum anti-AT1,α1,β1,and M2 receptor autoantibodies in patients with diabetic nephropathy,and to assess the relationship between the above indicators and renal function damage.Methods A total of 120 diabetic patients admitted to the hospital from January 2017 to January 2019 were selected and divided into observation group and control group according to the differences in their condition.The observation group had diabetic nephropathy(n=60),and the control group had no diabetic nephropathy(n=60).In addition,60 healthy adults who received physical examination in the hospital during the same period were selected as a parallel group.Compare the positive rates of autoantibodies against AT1,α1,β1 and M2 receptors in the three groups.Results The positive rate of serum anti-AT1,α1,β1 and M2 receptor autoantibodies in the observation group was higher than that of the control group and the parallel group(P<0.05);the positive rate of serum anti-AT1 receptor autoantibodies in the control group was higher than that In the parallel group,the positive rate ofα1,β1 and M2 receptor autoantibodies was lower than that in the parallel group(P<0.05).Conclusion The positive rate of serum anti-AT1,α1,β1 and M2 receptor autoantibodies in diabetic patients is abnormal,and the positive rate of serum anti-AT1,α1,β1 and M2 receptor autoantibodies was higher in patients with diabetic nephropathy.

关 键 词：糖尿病肾病 血清AT1抗体 受体自身抗体 血清α1抗体 

分 类 号：R59[医药卫生—内科学]