银杏二萜制剂联合丁苯酞治疗急性进展型脑卒中的临床研究  

Clinical Study of Ginkgolides Sodium Chloride Injection Combined with Butylphthalide in the Treatment of Acute Progressive Stroke

作　　者：肖辉[1] 姜山[1] 孙娜[1] 陈隐漪[1] XIAO Hui;JIANG Shan;SUN Na;CHEN Yinyi(Dept.of Neurology,Lianyungang Hospital Affiliated to Nanjing University of Chinese Medicine,Jiangsu Lianyungang 222004,China)

机构地区：[1]南京中医药大学连云港附属医院神经内科,江苏连云港222004

出　　处：《中国医院用药评价与分析》2020年第9期1100-1102,1106,共4页Evaluation and Analysis of Drug-use in Hospitals of China

摘　　要：目的:探讨银杏二萜制剂联合丁苯酞治疗急性进展型脑卒中的临床效果。方法:选取2017年10月至2019年9月于南京中医药大学连云港附属医院神经内科治疗的急性进展型脑卒中患者82例为研究对象,采用随机数字表法分为对照组与观察组,每组41例。对照组患者给予丁苯酞治疗,观察组患者在对照组的基础上加用银杏二萜制剂治疗。比较两组患者的临床疗效,治疗前后神经功能改善情况[美国国立卫生院卒中神经功能缺损评分量表(national institutes of health stroke scale,NIHSS)评分]、凝血功能指标[纤维蛋白原(FIB)、凝血酶原时间(PT)和凝血酶时间(TT)]水平、同型半胱氨酸(HCY)及D-二聚体水平的差异,对患者进行2个月的随访,评价其预后情况。结果:治疗前,两组患者NIHSS评分、凝血功能指标水平、HCY及D-二聚体水平的差异均无统计学意义(P>0.05)。观察组患者治疗后NIHSS评分明显低于对照组,差异有统计学意义(P<0.05)。观察组患者的总有效率为90.24%(37/41),明显高于对照组的73.17%(30/41),差异有统计学意义(P<0.05)。治疗后,观察组患者FIB水平明显高于对照组,PT、TT明显短于对照组,差异均有统计学意义(P<0.05)。治疗后,观察组患者HCY、D-二聚体水平明显低于对照组,差异均有统计学意义(P<0.05)。观察组患者的预后良好率为75.61%(31/41),明显高于对照组的53.66%(22/41),差异有统计学意义(P<0.05)。结论:银杏二萜制剂联合丁苯酞治疗急性进展型脑卒中的效果肯定,可降低患者神经功能损伤,提高预后效果。OBJECTIVE:To probe into the clinical effects of ginkgolides sodium chloride injection combined with butylphthalide in the treatment of acute progressive stroke.METHODS:Totally 82 patients with acute progressive stroke admitted into neurology department of Lianyungang Hospital Affiliated to Nanjing University of Chinese Medicine from Oct.2017 to Sept.2019 were extracted to be divided into the control group and the observation group via the random number table,with 41 cases in each group.The control group was given butylphthalide,while the observation group additionally received ginkgolides sodium chloride injection based on the control group.The clinical efficacy,differences of neurological improvement[National Institutes of Health Stroke Scale(NIHSS)score],coagulation function indicators[fibrinogen(FIB),prothrombin time(PT)and thrombin time(TT)]levels,homocysteine(HCY)and D-dimer levels before and after treatment were compared.Patients were followed up for two months to evaluate the prognosis.RESULTS:Before treatment,there was no significant difference in NIHSS score,coagulation function indicators,HCY and D-dimer levels between two groups(P>0.05).After treatment,the NIHSS score in the observation group was significantly lower than that in the control group,and the difference was statistically significant(P<0.05).The total effective rate of the observation group was 90.24%(37/41),significantly higher than that of the control group 73.17%(30/41),and the difference was statistically significant(P<0.05).After treatment,the level of FIB in the observation group was significantly higher than that in the control group,and the levels of PT and TT were significantly shorter than those in the control group,the difference was statistically significant(P<0.05).After treatment,the levels of HCY and D-dimer in the observation group were significantly lower than those in the control group,and the differences were statistically significant(P<0.05).The good prognosis rate of patients in the observation group was 75.61%(31/41),si

关 键 词：银杏二萜制剂 丁苯酞 脑卒中 神经功能 

分 类 号：R932[医药卫生—生药学]