碳青霉烯类耐药肠杆菌科细菌的检测方法  

Determination methods for carbapenem-resistant Enterobacteriaceae

作　　者：周宏伟[1] 胡燕燕[1] 张嵘[1] ZHOU Hongwei;HU Yanyan;ZHANG Rong(Department of Clinical Laboratory,the Second Affiliated Hospital of Zhejiang University School of Medicine,Hangzhou 310009,Zhejiang,China)

机构地区：[1]浙江大学医学院附属第二医院检验科,浙江杭州310009

出　　处：《检验医学》2020年第10期971-973,共3页Laboratory Medicine

摘　　要：由碳青霉烯类耐药肠杆菌科细菌(CRE)引起的感染给临床治疗带来了巨大挑战。及时、准确地鉴别出产何种碳青霉烯酶,对指导临床抗感染治疗有至关重要的意义。目前,碳青霉烯酶的检测方法主要为表型筛选、基因检测和基于基质辅助激光解吸电离飞行时间质谱(MALDI-TOF MS)技术的检测方法。文章对CRE的各类检测方法进行综述。The infection caused by carbapenem-resistant Enterobacteriaceae(CRE)brings a challenge for clinical treatment,and timely and accurately identifying carbapenemase plays a role in guiding clinical antibiotic application.At present,the determination methods of carbapenemase include phenotypic screening,gene determination and the methods based on matrix-assisted laser desorption/ionization time-of-flight mass spectrometry(MALDI-TOF MS).This review focuses on various determination methods for CRE.

关 键 词：碳青霉烯类耐药 肠杆菌科细菌 检测方法 

分 类 号：R446.5[医药卫生—诊断学]