Ⅲ型前列腺炎患者EPS中VIP、锌离子、MIF、TNF-α表达的相关意义研究  

Correlation between VIP, zinc ion, MIF and TNF-alpha in EPS of patients with type Ⅲ prostatitis

作　　者：李路鹏 李晓光 徐国良 焦志灵 王连渠 LI Lupeng;LI Xiaoguan;XU Guoliang;JIAO Zhiling;WANG Lianqu(Department of Urology,First Affiliated Hospital of Henan University,Kaifeng,Henan 475000)

机构地区：[1]河南大学第一附属医院泌尿外科,河南开封475000

出　　处：《实验与检验医学》2020年第5期857-859,875,共4页Experimental and Laboratory Medicine

基　　金：河南省医学科技攻关计划项目,编号201203082。

摘　　要：目的探讨Ⅲ型前列腺炎患者前列腺按摩液(EPS)中的血管活性肠肽(VIP)、锌离子、巨噬细胞移动抑制因子(MIF)、肿瘤坏因子-α(TNF-α)的水平变化及其临床意义。方法选取我院2015年1月至2016年12月收集的140例Ⅲ型前列腺炎患者(病例组)、健康男性70例(对照组),检测并比较两组的EPS中VIP、锌离子、MIF、TNF-α水平,并将病例组分为ⅢA型、ⅢB型进行分层分析,探讨EPS中4指标水平与患者临床症状的关系。结果病例组患者的EPS中的VIP、MIF、TNF-α水平均显著的高于对照组(P<0.05),病例组患者的EPS中的锌离子水平均显著的低于对照组(P<0.05);ⅢA型患者的EPS中的VIP、TNF-α水平均显著的高于ⅢB型患者(P<0.05),ⅢA型患者的EPS中的锌离子、MIF水平与ⅢB型患者差异不具有统计学意义(P>0.05);ⅢA型患者的NIH-CPSI评分、IPSS评分与ⅢB型患者差异不具有统计学意义(P>0.05);Ⅲ型患者的NIH-CPSI评分、IPSS评分与EPS中的VIP、MIF水平呈显著的正相关关系(P>0.05),与锌离子呈显著的负相关关系(P<0.05)。结论Ⅲ型前列腺炎患者EPS中VIP、锌离子、MIF、TNF-α水平较健康男性发生显著改变,并且EPS中VIP、锌离子、MIF与患者疾病分型及病情严重程度有关。Objective To investigate the changes of VIP, zinc ion, MIF and TNF-alpha in EPS of patients with type Ⅲ prostatitis and their clinical significance. Methods One hundred and forty cases of type Ⅲ prostatitis(case group) and 70 healthy men(control group) were collected from January 2015 to December 2016 in our hospital. The levels of VIP, zinc ion, MIF and TNF-alpha in EPS of two groups were detected and compared,the cases were divided into three types: type A and type Ⅲ B, to investigate the relationship between VIP, zinc ion, MIF and TNF-alpha in EPS and clinical symptoms. Results The levels of VIP,MIF and TNF-alpha in EPS of case group were significantly higher than those of control group(P<0.05). The level of zinc in EPS of case group was significantly lower than that of control group(P<0.05). The levels of VIP and TNF-alpha in EPS of patients with type Ⅲ A were significantly higher than those of patients with type Ⅲ B(P<0.05). The levels of zinc and MIF in EPS of type Ⅲ A patients were not significantly different from those of patients with type Ⅲ B(P>0.05). The NIH-CPSI score and IPSS score of patients with type Ⅲ A were not significantly different from those of patients with type Ⅲ B(P>0.05). There was a significant positive correlation between the NIH-CPSI score and IPSS score of type Ⅲ patients and the levels of VIP and MIF in EPS(P>0.05).There was a significant negative correlation between Zn and above mentioned index(P<0.05). Conclusion The levels of VIP, zinc,MIF and TNF-in EPS in patients with type Ⅲ prostatitis were significantly higher than those of healthy men, and VIP, zinc and MIF in EPS were related to the classification of the patients and the severity of the disease.

关 键 词：Ⅲ型 前列腺炎 血管活性肠肽 锌离子 巨噬细胞移动抑制因子 肿瘤坏因子-α 

分 类 号：R446.112[医药卫生—诊断学] R69733[医药卫生—临床医学]