下肢静脉血栓栓塞患者利伐沙班治疗前后血浆F1+2、Fg、DD水平表达及意义  

Expression and Significance of Plasma F1+2,Fg and DD Levels in Patients with Lower Extremity Venous Thromboembolism Before and After Rivaroxaban Treatment

作　　者：王飞[1] WANG Fei(Department of Laboratory Medicine,Anyang People's Hospital,Anyang,Henan Province,455000)

机构地区：[1]安阳市人民医院检验科,河南安阳455000

出　　处：《实验与检验医学》2020年第5期868-871,共4页Experimental and Laboratory Medicine

摘　　要：目的探讨下肢静脉血栓栓塞(VTE)患者利伐沙班治疗前后血浆凝血酶原片段1+2(F1+2)、纤维蛋白原(Fg)、D-二聚体(DD)水平表达及意义。方法选取2017年12月-2019年10月我院下肢VTE患者318例为试验组,同期选取168例健康体检者为对照组,统计对比两组入院时血浆F1+2、Fg、DD水平,并将试验组按随机数字表法均分为A组、B组、C组,各106例,A组口服15 mg利伐沙班,2次/d,连用3周后,增加至20 mg/次,1次/d,B组口服20 mg利伐沙班,1次/d,C组口服10 mg利伐沙班,1次/d,持续治疗3个月,统计3组治疗前、治疗3 d、7 d后血浆F1+2、Fg、DD水平与上述血浆指标恢复正常时间、影像学检查转阴人数、出血事件、下肢VTE复发率。结果⑴试验组入院时血浆F1+2、Fg、DD水平高于对照组(P<0.05);⑵A组治疗3 d、7 d后血浆F1+2、Fg、DD水平低于B组、C组(P<0.05);⑶A组血浆F1+2、Fg、DD水平恢复正常时间短于C组、B组(P<0.05),A组、C组影像学检查转阴人数比例高于B组(P<0.05);⑷3组出血事件(均为非严重出血事件)、下肢VTE复发率相比,差异无统计学意义(P>0.05)。结论下肢VTE患者血浆F1+2、Fg、DD呈高表达,经利伐沙班治疗后呈降低趋势,并未出现严重出血事件,可作为临床治疗下肢VTE有效途径。Objective To investigate the expression and meaning of plasma prothrombin fragment 1+2(F1+2),fibrinogen(Fg)and D-dimer(DD)before and after rivaroxaban treatment in patients with lower extremity venous thromboembolism(VTE).Methods From December 2017 to October 2019,318 patients with lower extremity VTE in our hospital were selected as the experimental group.168 healthy subjects were selected as the control group.The plasma F1+2,Fg and DD levels were compared between the two groups.The experimental group was divided into group A,group B and group C according to the random number table method,106 cases each.Group A received 15 mg rivaroxaban twice a day for 2 weeks.After 3 weeks,it was increased to 20 mg/time,1 time/d;group B oral 20 mg rivaroxaban,1 time/d;group C oral 10 mg rivaroxaban,1/d.After 3 months of treatment,the levels of plasma F1+2,FIB and DD,the time of recovery of the above plasma indexes,the number of patients with negative imaging examination,bleeding events and the recurrence rate of VTE in lower limbs were counted before treatment,3 days and 7 days after treatment.the number of imaging examinations turned negative,bleeding events,and lower limb VTE recurrence rate.Results(1)The levels of plasma F1+2,Fg and DD in the experimental group were higher than those in the control group(P<0.05).(2)The comparison of age,sex and body mass in group A,group B and group C,the difference was no statistical significance(P>0.05).(3)The levels of plasma F1+2,Fg and DD in group A were lower than those in group B and C(P<0.05)for 3 days and 7 days after treatment.(4)The normal recovery time of F1+2,Fg and DD levels in plasma of group A was shorter than that of C group and B group(P<0.05).The proportion of negative imaging patients in group A and group C was higher than that in group B(P<0.05);(5)3 There was no significant difference in the rate of recurrence of VTE between the group(both non-severe bleeding events)and lower extremity(P>0.05).Conclusion The plasma F1+2,Fg and DD of patients with lower extremity VTE ar

关 键 词：静脉血栓栓塞 利伐沙班 F1+2 FG DD 维生素K拮抗剂 低分子肝素 

分 类 号：R446.1[医药卫生—诊断学] R543.6[医药卫生—临床医学]